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P588. The prevalence and risk factors of low bone mineral density in a Slovak IBD cohort

Background

Osteoporosis and osteopenia are known chronic extraintestinal complications of inflammatory bowel diseases (IBD). The aetiology of bone loss in IBD patients is not properly clarified.

Methods

The aim of our study was to describe the prevalence of reduced bone mineral density (BMD) in IBD patients and to identify its risk factors. The cohort consisted of 150 IBD patients, 89 with Crohn's disease (CD) and 61 with ulcerative colitis (UC). Clinical characteristics of every patient were recorded i.e. age, sex, duration of the disease, clinical behaviour, location of disease according Montreal classification, surgeries, steroid medication, sIBDQ, smoking habits. The BMD was determined by dual-energy X-ray absorptiometry (DXA) at the lumbar spine and femoral neck.

Results

The average BMD at lumbar spine was 0.964±0.113 g/cm2 and 0.879±0.131 g/cm2 at total femur. Average T score was −1.0±1.0 at lumbar spine and −0.5±1.0 at total femur. The prevalence of osteopenia (T score −1 to −2.5) in our cohort was found in 69/150 (46%) patients and osteoporosis in 15/150 (10%) patients. In a subgroup of UC patients osteopenia was present in 30/61 (49%) and osteoporosis in 5/61 (8%) patients. In a subgroup of CD patients osteopenia was present in 39/89 (44%) and osteoporosis in 10/89 (11.2%) patients. In a multivariate logistic regression, the osteoporosis was associated only with duration of the disease OR = 1.07 per year of disease duration (95% CI 1.01–1.14), p = 0.03. Low BMD was associated with duration of disease, OR = 1.06 per year (95% CI 1.01–1.13). There was a trend for menopause as an independent risk factor p = 0.08 (OR 2.63).

Conclusion

The prevalence of low BMD in our IBD cohort was more than 55%

  • Written by:

    A. Krajcovicova, T. Hlavaty, Z. Killinger, E. Miznerova, J. Toth, D. Cierny, T. Koller, J. Letkovsky, Z. Zelinkova, M. Huorka, J. Payer, University Hospital Bratislava, 5th Department of Internal Medicine, Bratislava, Slovakia