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P590. The features of IBD in young patients - evaluation of a batch of more than 1,000 patients

Background

Inflammatory bowel disease (IBD) can be painful and debilitating, and sometimes leads to life-threatening complications. The incidence of inflammatory bowel disease (IBD) is increasing among young people especially Crohn's disease.

Methods

We used the data from a prospective multicenter study developed between 2006–2013, on 1077 patients diagnosed with inflammatory bowel disease in which we evaluated the prevalence of Crohn's disease, and Ulcerative Colitis, the complications (intestinal and extraintestinal) that occurred and the disease severity. We divided the batch into two groups according the age (under the age of 40 and over 40 years old) to find the disease features in young patients.

Results

We analyzed 493 (46%), patients under the age of 40 in which 236 patients (48%), were diagnosed with Ulcerative Colitis and 221 (52%) with Crohn's disease. In the second group we analyzed 584 (54%) 40 years old patients and over in which 378 patients (65%), were diagnosed with Ulcerative Colitis and 187 (35%) with Crohn's disease. We found a statistic significant higher incidence of Crohn's disease in young patients (p < 0.0001). Indeterminate colitis was more frequent in young patients (36/493 vs 19/584 p = 0.003). Intestinal complications had the same incidence in the two groups (152/493 vs 187/584, p 0.69, NS). However, perianal fistulas (46/493 vs 27/584, p 0.007) and abscesses (20/493 vs 7/584, p 0.003) were found more frequently in younger patient. Severe bleeding was more common in patients over 40 years (125/584 vs 80/493, p = 0.03), and malignant transformation has not been reported in patients under the age of 40 years. The most important aspect is the disease severity - we counted more severe cases in the younger group - Ist group - 211 mild cases and 282 severe diseases vs 298 mild and 296 severe in the second group, p = 0.008.

Conclusion

In young IBD patients, Crohn's disease was diagnosed in about half of patients, with a significant higher incidence than in over 40 years old group. Indeterminate colitis is more often diagnosed in young patients. Younger IBD patients had more severe disease, and more complications than the patients over 40 years old.

  • Written by:

    A. Goldis1, D. Dobru2, L. Gheorghe3, C. Gheorghe3, C. Chijevschi4, M. Tantau5, G. Constantinescu3, I. Ratiu1, D. Lazar1, R. Iacob3, M. Diculescu3, on behalf of the IBDPROSPECT Study Group, 1University of Medicine Timisoara, Gastroenterology, Timisoara, Romania, 2University of Medicine Targu Mures, Gastroenterology, Targu Mures, Romania, 3University of Medicine Bucharest, Gastroenterology, Bucharest, Romania, 4University of Medicine Iasi, Gastroenterology, Iasi, Romania, 5University of Medicine Cluj-Napoca, Gastroenterology, Cluj-Napoca, Romania