P594. The epidemiology of inflammatory bowel disease in children of Manitoba: 30 years' experience
Over the last few decades, the incidence of inflammatory bowel disease has been rising. The aim of this study was to describe the incidence and prevalence of inflammatory bowel disease (IBD) in children <17 years in the central Canadian province of Manitoba over 30 years from 1978–2007.
From January 1, 1978 to December 31, 2007, the sex and age-adjusted annual incidence and prevalence of paediatric IBD per 100,000 of population were determined. The Province of Manitoba annual health statistics were used to calculate population estimates for participants. To ensure validity of data, the University of Manitoba IBD Epidemiology Database was analyzed for patients <17 years of age at diagnosis from 1989 to 2000.
The sex and age-adjusted incidence of paediatric Crohn's disease (CD) has increased from 1.2 per 100,000 in 1978 to 4.68 per 100,000 in 2007. For ulcerative colitis (UC) the incidence has increased from 0.47 per 100,000 in 1978 to 1.64 per 100,000 in 2007. During the same time period, the prevalence of CD has increased from 3.1 to 18.9 per 100,000 and from 0.7 to 12.7 per 100,000 for UC. During the last 5 years of the study the average annual incidence of IBD in urban patients was 8.69/100,000 as compared to 4.75/100,000 for rural patients (p < 0.001). This difference was consistent during the entire study period. About one third of patients had a family history of IBD.
The incidence and prevalence of paediatric IBD in Manitoba is rising. The majority of our patients were residents of urban Manitoba confirming the important role of environmental etiologic factors.