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P596. Risk factors for depression and anxiety in Crohn's disease


Crohn's disease (CD) is a long-life inflammatory disease affecting gastrointestinal tract, characterised by extraintestinal manifestations and complications that impaired quality of life. Many patients are affected by psychiatric co-morbidity too, in particular depression and anxiety. A few studies have investigated mood disorders in CD. The aim of our study was to assess prevalence of depression and anxiety and related risk factors in a consecutive series of patients with quiescent CD.


It was a prospective cohort study in which we enrolled 185 consecutive patients, regularly followed in a tertiary centre for IBD care, with confirmed diagnosis of CD, in clinical remission, aged from 18 to 80 years. Eligible patients were enrolled during ambulatory visits assessing demographic and clinical features of CD. Within 1 month from the visit, patients were interviewed by phone to assess the presence of psychiatric disorders using standardized questionnaires: the Hospital Anxiety and Depression Scale (HADS) and a questionnaire assessing the use of antidepressant or anti-anxiety therapy during the course of CD. Development of anxiety and depression was defined by HADS ≥8 or by the use of antidepressant or anti-anxiety treatment since diagnosis. Statistical analysis were performed by Kruskall-Wallis test, Bonferroni correction, χ2 test, p-value <0.05 was considered statistically significant.


One hundred eighty-five patients were included in the study and 73 patients (39.5%) showed mood disorders since diagnosis. Thirty-four patients (18.4%) have been under psychiatric treatment since diagnosis. Anxiety/depression were significantly correlated with female sex (p:0.016), history of perianal disease (p:0.006) and perianal surgery (p:0.03). Smokers showed a high, although not significant, prevalence of anxiety/depression compared with patients without mood disorders (p:0.08). Anxiety with or without depression was more significantly correlated with perianal disease and female sex whilst depression alone wasn't significantly correlated with any variable considered in the study. We didn't find significant relationship between surgery and anxiety/depression.


Among psychiatric disorders, anxiety is the most frequent condition in patient affected by CD in clinical remission. Risk factors for anxiety/depression were female sex and history of perianal disease and perianal surgery.

  • Written by:

    F. Furfaro1, D. Gridavilla1, C. Bezzio1, L. Orlandini1, A. Dell'Era2, M. Monteleone1, S. Ardizzone1, G. Maconi1, 1Luigi Sacco University Hospital, Gastroenterology and IBD Unit, Milan, Italy, 2Luigi Sacco University Hospital, Gastroenterology Department, Milano, Italy