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P599. Prevalence of iron deficiency anemia and iron deficiency in a single center Turkish IBD cohort

Background

Anemia is the most common complication of inflammatory bowel diseases (IBD). The prevalence of anemia reported in previous publications varies from 17% to 68%. In recent years, anemia in IBD has became one of the major interests as it effects the quality of life and outcome of treatments in IBD patients. The aim of this study was to analyse the prevalence of iron deficiency anemia and iron deficiency in an out-patient single centre IBD cohort.

Methods

We evaluated 398 consecutive IBD patients (Crohn's Disease (CD): 186 patients, Ulcerative Colitis (UC): 212 patients) admitted to our outpatients clinic. Demographic and clinical characteristics of each patient was evaluated and recorded. Hemoglobin and hematocrit levels, serum concentrations of iron, ferritin, vitamin B12 and serum CRP levels were recorded. Anaemia was defined as Hb <120 g/L, iron deficiency was defined as ferritin levels <20 and Vit B12 deficiency was defined as <200 mg/dl. Then, we analysed the prevalence of anemia and its predictors.

Results

The prevalence of anemia in our cohort of IBD patients was 22% in UC patients and 24% in CD patients. There was no significant difference in anemia prevalence between CD and UC. There was a trend for significance for the occurrence of anemia in UC extensive colitis when compared to ulcerative proctitis. Ileal involvement in CD was associated with a significantly higher rate of anemia. For iron deficiency without anemia, we found that 47% of UC patients and 41% of CD patients were experiencing iron deficiency without anemia. Vitamin B12 deficiency was observed as 10% and 17% of the patients respectively in UC and CD. In our cohort; 10% of UC patients and 29.6% of CD patients were receiving anti-TNF treatments. In addition; 21.5% of all IBD patients were receiving immune modulatory medicines. We observed no association with AZA or other medication.

Conclusion

In conclusion; The prevalence of anemia and iron deficiency in an out-patient IBD cohort was found to be relatively high. Anemia and iron deficiency were seemed to be associated with ileal involvment in CD, there was a trend towards significance in extensive colitis in UC.

  • Written by:

    M. Törüner, C. Kalkan, O. Keskin, H. Cetinkaya, I. Soykan, Ankara University School of Medicine, Department of Gastroenterology, Ankara, Turkey