P600. Prevalence of anemia in children with inflammatory bowel disease in Russian Federation
Anemia is a common complication of inflammatory bowel disease, although the reported prevalence of this condition has been markedly variable. However, the existing data in children are still limited. The aim of this study was to determine and analyze the prevalence of anemia for hospitalized children patients diagnosed with IBD in 2010–2013 years in Scientific Centre of Children Health in Moscow, Russia.
The study included 186 children diagnosed with IBD aged 6 months to 18 years (mean age was 12±4.6 years): 94 of them presented Crohn's disease (CD) and 92 - ulcerative colitis (UC). Patients were divided into 2 groups, anemic and non-anemic. Anemia was defined as an hemoglobin level lower than the normal value of the laboratory of our hospital (based on the World Health Organization criteria). The influence of type of IBD, age, gender, time from diagnosis, disease activity, undergoing treatment were evaluated.
In all, one-third of patients with IBD were anemic. There was no significant difference in prevalence of anemia between CD (33%) and UC (29%) patients. Mean haemoglobin in the anemic UC and CD group was 9.6 (8.5–11.0) g/dL and 10.3 (9.3–10.6) g/dL respectively. Gender difference has not been observed among anemic IBD patients. Anemia was most common in children under 3 years of age (61%). The prevalence of anemia in older children and adolescents was 28%. Most patients with UC and CD had moderate form of anemia (71% with CD and 52% with UC). Anemia was more common at diagnosis than during follow-up (45% and 28%, respectively, P = 0.001). Disease activity scores (PUCAI; PCDAI) showed an inverse correlation with hemoglobin level. Patients with mild, moderate and severe UC disease activity were anemic in 19%, 44%, 62% cases respectively. The same inverse correlation was for CD. Compared with the IBD patients who received corticosteroid drugs, the children who received anti-TNF-a treatment (infliximab) with the same disease activity score had lower rates of anemia (55% vs. 37.5%).
Anemia was present in every third IBD patient and remains a frequently associated pathology to the inflammatory bowel disease, especially in infants and young children, that requires specific management.