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P613. Incidence study and follow-up of a cohort of patients with inflammatory bowel disease (IBD) in Malaga (Spain)

Background

Knowledge of incidence rates (IR) and follow-up of patients are important issues in IBD. IR may differ between regions and this may involve different resource requirements.

Methods

Prospective study of incidence, and 3-year follow. All patients with onset of IBD in the years 2007 and 2008 in our hospital area with a population of 450000 people were included. All met the criteria of Lennard-Jones, personal history were collected and phenotypically classified according to the Montreal classification. They were followed every 3–6 months. Crude and standardized incidences were calculated. Patients independent variables, phenotypic characteristics of the disease and therapeutic needs are related in evolution.

Results

79 patients were diagnosed with IBD. 34 ulcerative colitis (UC) and 45 Crohn's disease (CD). The mean age at diagnosis was 35.6 years 95% CI (32.1–39.26) for all patients; 43.97 IC (38.07–49.87) for UC and 29.4 CI (25.95–32.85) for CD. The crude incidence for IBD in our cohort was 8.96/105. 3.86/105 for UC and 5.1/105 for CD. The standardized incidence of IBD for ages between 15 and 64 years was 12.36/105 CI (9.66–15.57). 4.8/105 CI (3.24 to 6.9) for UC and 7.56/105 CI (5.5 to 10.22) for CD.

Among CD patients 42.2% were smokers compared to 8.82% of UC patients (p < 0.001).

CD showed statistically significant association with immunomodulatory therapy (p = 0.009) and hospitalization need (p = 0.013) during follow-up of the cohort. No statistical significance was obtained regarding the need for biological therapy or surgery.

Statistically significant association between smoking and need for hospitalization was also found in CD (p = 0.004). There is also a significant association between younger age at diagnosis and biological therapy need (p = 0.022) and between B3 pattern and need for immunomodulatory therapy (p = 0.009). The B1 pattern was associated with less hospitalization (p = 0.049) and less need for surgery (p = 0.018).

For UC no statistically significant association between the independent variables of the patients, disease phenotype and therapeutic needs was found.

Conclusion

In our hospital area of southern Spain incidence rates are similar to other areas of southern Europe. However Greater incidence of Crohn's disease with respect to UC is described. Crohn's disease requires more aggressive therapy than CU (immunomodulators and surgery). An early age at diagnosis is associated with greater need for biologic therapy.

  • Written by:

    I. Cueto Torreblanca1, M. Gutierrez Bedmar2, R. Camargo Camero1, J.V. Martos Vandusen1, R.J. Andrade Bellido1, G. Alcaín Martínez1, 1Hospital Universitario Virgen de la Victoria, Gastroenterology, Malaga, Spain, 2Universidad de Malaga, Medicina Preventiva, Malaga, Spain