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P618. Impact of depression on medication adherence in inflammatory bowel disease


Patients with Inflammatory Bowel Disease (IBD) are at high risk for poor adherence. Non-adherence to medication is an important challenge in the treatment of IBD and has a substantial impact on the course of the disease. The aim of our study was to assess the adherence level in IBD patients and to identify impact of depression on adherence level in a single tertiary center.


A total of 200 outpatients (98 men, 102 women) with IBD (105 with Crohn's disease and 95 with ulcerative colitis), aged 18–65 years, treated at a tertiary referral centre of the University Clinical Centre “Zvezdara” (Serbia) were enrolled. Medication adherence was assessed using Morisky Medication Adherence Scale (MMAS-8). The levels of depression were obtained by the Hamilton Depression Rating Scale (HAMD-21). Statistical analyses were performed using SPSS software package.


Based on MMAS-8 responses, we identified 78 patients as low adherers (LAs) and 122 patients as medium or high adherers (MHAs). There was no statistically significant difference between UC and CD according levels of adherence (p > 0.01). There was no statistically significant diferrences between LAs and MHAs according levels of depression (HAMD-score) (p > 0.01).


About 40%

  • Written by:

    L. Trikos1, D. Bojic2, V. Gligorijevic2, S. Markovic2, N. Jojic2, 1University Clinical Centre “Zvezdara”, Center of psychiatry, Belgrade, Serbia, 2University Clinical Centre “Zvezdara”, Department of Gastroenterology and Hepatology, Belgrade, Serbia