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P625. Features of familial Crohn's disease: A comparative retrospective study

Background

Crohn's disease (CD) is a chronic inflammatory bowel disease whose etiology is thought to be multifactorial. Familial aggregation in CD strongly suggests that genetic factors play a crucial role in pathogenesis of this disease. The aim of our study was to compare familial and sporadic cases regarding clinical and therapeutic characteristics of CD.

Methods

We have conducted a retrospective study including hospitalized CD patients from 2007 to 2012. Familial form (FF) of CD was diagnosed in patients whose 1st or 2nd or 3rd degree relatives have inflammatory bowel disease: CD or ulcerative colitis (UC).

Results

Two hundred seventy-five patients (143 males and 132 females) were colliged. Mean age was 31.8 years old [8–65]. They were followed during a mean period of 23.3 months. Familial form (FF) of CD was diagnosed in 32 patients (11.6%). Age at onset of CD, site and phenotype of CD were similar in FF and sporadic forms (SF) (respectively p = 0.2, p = 0.6 and p = 0.9). Upper gastrointestinal tract involvement, anoperineal lesions and complications such as abcess and severe acute colitis were as common in FF as in SF of CD. Extraintestinal manifestations were significantly more frequent in FF than SF (45.1% versus 21.5%, p = 0.005). Corticosteroids were more commonly prescribed in FF than in SF (75% versus 55%, p = 0.026). Overall, patients with FF receive more immunosuppressive therapy than patients with SF (65.6% versus 48.5%, p = 0.05) mainly methotrexate (12.5% versus 1.6%; p = 0.008). There was no difference between FF and SF of CD with regard of Biotherapy with anti-TNF agents (15% versus 8%; p = 0.1) and surgery (8% versus 35%, p = 0.2).

Conclusion

Despite comparable clinical characteristics of both groups, extraintestinal manifestations may result in more common use of corticosteroids and immunosuppressive therapy in FF than in SF of CD.

  • Written by:

    M. Serghini1, A. Labidi1, L. Zouiten1, N. Ben Mustapha1, M. Fekih1, J. Boubaker1, A. Filali1, 1La Rabta Hospital, Gastroenterology A, Tunis, Tunisia