P629. Epidemiological features and disease related concerns of a large cohort of Italian patients with active Crohn's disease
A large Survey on Quality Of Life in Crohn's PatiEnts (SOLE) is being conducted in Italy on patients with active Crohn's disease (CD) with the aim of assessing health-related QoL over a 12-month period. Namely, patients' perception of their experience and discomfort, as a number of social, cultural and psychological factors, was gathered. Here we report the results of ad interim analysis performed at baseline, to describe the demographic, social and disease characteristics of the study population, and their correlation with the disease-related worries.
Adults with active moderate-to-severe CD (Harvey–Bradshaw Index [HBI] ≥8) were consecutively recruited in 38 Italian IBD centres. The Rating Form of Inflammatory Bowel Disease Patient Concerns (RFIPC) was administered at baseline to assess CD-related worries, higher score representing worse worries. Results were correlated with demographic and clinical variables. One-way analysis of variance (ANOVA), t-tests, and linear regression analyses were used when appropriate.
552 patients with active CD (51% males, mean age 40±14 y, range 18–84 y) were recruited. 86% were living in family, 15% had a caregiver; 54% were employed while 14% unemployed. 368 patients (67%) had a high school diploma or degree. Active and former smokers were 213 (39%), and 124 (23%) respectively; alcohol consumers were 109 (20%). Inflammation involved the ileum and colon in 262 patients (48%) or terminal ileum in 192 patients (35%). 242 patients (44%) had undergone surgery before study inclusion. Mean HBI was 10.3 (SD ±3.2; range 8–39). More than an half of patients reported extraintestinal manifestations, including immune-mediated disease (such as psoriasis, rheumatoid arthritis, etc), one fourth of them had no comorbidities, while the rest of the patients had other concomitant diseases (such as diabetes, hypertension, etc). The highest rated worries included having an ostomy bag, undergoing surgery and fear not to achieve ‘full potential’ (mean RFIPC scores 69%, 68% and 66%, respectively). Variables associated with a higher global RFIPC score based on a linear regression model included female sex (p < 0.0001), presence of any comorbidity (p = 0.00128), disease activity (p < 0.0001), and low adherence (defined as Medication Adherence Rating Score <25, p < 0.0001).
This ad interim analysis underlines that major determinants of disease-related worries in Italian CD patients include female gender, degree of activity of the disease, presence of comorbidities, and low adherence to treatment. These preliminary results underline patients' disease-related worries and may help to understand the importance of empowering patient/physician relationships.
A. Armuzzi1, G. Riegler2, M. Vecchi3, M. Baldoni4, F. Costa5, M. Fortuna6, F. Furfaro7, G. Iaquinto8, P. Paese9, C. Papi10, F. Rizzello11, V. Tornatore12, F. Bossa13, 1Catholic University, IBD Unit, Complesso Integrato Columbus, Rome, Italy, 2Second University of Naples, Gastroenterology, Naples, Italy, 3IRCCS Policlinico San Donato, Gastroenterology, Milan, Italy, 4University of Perugia, Gastroenterology, Perugia, Italy, 5Azienda Ospedaliero-Universitaria Pisana, Gastroenterology, Pisa, Italy, 6Hospital Sacro Cuore Don Calabria, Gastroenterology, Negrar-Verona, Italy, 7University Hospital L. Sacco, Gastroenterology, Milan, Italy, 8Azienda Ospedaliera San Giuseppe Moscati, Gastroenterology, Avellino, Italy, 9Azienda Ospedaliera di Cosenza, Gastroenterology, Cosenza, Italy, 10Azienda Ospedaliera San Filippo Neri, Gastroenterology, Rome, Italy, 11University of Bologna, Dipartimento di Scienze Mediche e Chirurgiche (DIMEC), Bologna, Italy, 12AbbVie srl, Medica Department, Campoverde di Aprilia, Italy, 13Ospedale Casa Sollievo della Sofferenza, Gastroenterology, San Giovanni Rotondo, Italy
- Posted in: Poster presentations: Epidemiology (2014)