P638. Characteristics of Gipsy pediatric patients with inflammatory bowel disease (IBD) based on the nationwide, prospective Hungarian pediatric IBD registry (HUPIR)
Based on hygiene theory, it was supposed that incidence of IBD in Gipsy patients is low. Nevertheless, incidence of pediatric Gipsy patients with IBD is unknown. Our aim was to assess the incidence, age, gender, disease phenotype and localisation in pediatric Gipsy patients with IBD in comparison to Caucasian patients.
From 01. January 2007 to 31. December 2012 (6 years) demographic data and disease characteristics (Paris Classification) of newly diagnosed IBD patients younger than 18 years were prospectively registered. Patients were divided in Caucasian and Gipsy subgroups.
A total of 842 patients were identified [Crohn's disease (CD): 62.5%; ulcerative colitis (UC): 31.2%, IBD unclassified (IBD-U): 6.3%]. It is of interest, that distribution of CD and UC in Gipsy patients was similar which is in contrast to CD dominance of Caucasian patients: 756 Caucasians [CD: 64.2%; UC: 29.8%] and 86 Gipsies (11.4%) [CD: 47.7%, UC: 44.2%]. Incidence of IBD in Caucasians was 7.41, of CD: 4.74, of UC: 2.22, and of IBD-U: 0.45, respectively, per 100,000. Incidence of IBD in Gipsies: 4.78, CD: 2.28, UC: 2.11, IBD-U: 0.39, respectively, per 100,000. Median age in the two groups of patients was similar (CD: Caucasians: 14.01; Gipsies: 14.25; UC: Caucasians: 13.51, Gipsies: 12.6 years). There was no difference in localisation and behaviour of CD between gypsies and Caucasians. The extraintestinal manifestations were similar in the two groups studied (Gipsies: 19.5%, Caucasians, 15.1%).
The incidence of IBD in Gipsy patients is high. Nevertheless, distribution of CD and UC in Gipsy patients was similar, which is in contrast the higher CD rate in Caucasian patients. There was no significant difference of characteristics (localisation and behaviour) of IBD in Caucasian patients in comparison to Gipsy patients.