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P045 Quality of Life and Coping Mechanisms in patients with Crohn's Disease treated with Biological Therapy.

E. Geccherle*1, M. Fortuna2, R. Montanari3, A. Geccherle3

1Padova University, Department of General Psychology, Padova, Italy, 2San Camillo Hospital, Department of Gastroenterology, Trento (TN), Italy, 3Sacro Cuore Don Calabria Negrar Hospital, Multispecialistic Centre for Recto-Perineal Diseases (IBD Unit), Department of Gastroenterology,, Negrar (VR), Italy


Crohn's disease (CD) is a chronic and relapsing inflammatory bowel disorder with deep impact on health-related quality of life (QOL).

In the last few years several studies have focused the attention on patients (pts) subjective perception of health state, including emotional, social aspects and coping mechanisms related to the disease.

Nowadays improvement of pts' QOL is a new important goal in medical therapy.

The aim of this observational study is to investigate QOL and coping skills in patients with CD and the impact of the disease on working ability and daily activities.


We recruited 47 patients with moderate to severe CD (according to HBI Index) treated with biological therapy at the IBD Centre of Negrar Hospital (Verona, Italy).

All pts answered three questionnaires:

Short Form-36 (SF-36): a generic questionnaire which measures QOL and pts' health status.

Coping Orientation to Problems Experienced - New Italian Version (Cope-NVI): to measure different coping skills.

Work Productivity and Activity Impairment Questionnaire in CD (WPAI-CD): to measure

illness'impact on work productivity (physical impairment/ reduced productivity at


Hypotheses tested with statistical Methods (Z-test) are:

- Health-related QOL is good for the majority of pts.

- CD pts have the same coping skills of healthy people when dealing with a stressful situation.

- Work productivity is not compromised.


SF-36 indicates that the average score of this group of pts does not differ significantly from that of healthy individuals.

Cope NVI shows that coping mechanisms, when dealing with stressful events, are very similar in our CD pts group and in healthy people. Moreover, CD pts have the same standard deviation and overall score of healthy people.

Finally, the WPAI-CD questionnaire shows 22,15%h work loss in a week. Furthermore Work Productivity Loss, caused by disease's symptoms, is 17,15%h.

Regarding pts' daily routine 22,15%h reported difficulties in carrying out their every day's activities.


Interest in evaluating QOL in chronic disease pts is increasing.

Our study has demonstrated that health-related QOL and coping skills are similar in our group of pts and in healthy people.

Furthermore working ability and productivity is not significantly compromised.

These Results suggest that biological therapy can restore health-related QOL and improve daily activities, as shown in literature. However further studies are needed.