P101 Fecal Calprotectin is a valuable marker for detecting active Crohn`s disease with colon involvement
J. Tang*, X. Gao, M. Zhi, P. Hu
The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China
Fecal Calprotectin has been detected as a biomarker for active Crohn`s disease(CD). But its diagnostic value in different disease phenotype was not clear.
60 active CD (CDAI>150) patients were enrolled. Small bowel lesions were detected by CTE/MRE. Colon lesions were detected by ileocolonoscopy and Simple Endoscopic Score for Crohn's Disease (SES-CD) was assessed by an experienced endoscopist. Fecal Calprotectin(FC), Erythrocyte Sedimentation Rate (ESR), high sensitive C reactive protein(hs-CRP), Platelets count(PLT) were tested simultaneously.
80% patients had colon involvement (L1: n=12, 20%. L2+L3: n=48.80%). 26.7% had a stricturing or penetrating disease (B1: n=9, 15%. B2: n=8, 13%. B3: n=43, 72%).In patients with colon involvement, FC levels were correlated well with CDAI and SES-CD (P<0.01). ROC curve analysis indicated that for a FC cut-off of 350ug/g, the sensitivity for detecting active CD was 95% and the specificity was 80% (area under curve [AUC], 0.95; P<0.01) that was superior to hs-CRP,ESR and PLT. In patients with small bowel involvement only, although FC levels were correlated with CDAI (P<0.01), but ROC curve analysis indicated that FC was failed in detecting active CD. Among disease pattern, disease location, combination with abdominal complication, and SES-CD, multiple liner regression suggested that SES-CD was the only independent risk factor for high FC levels.
FC is a valuable surrogate marker for detecting active CD in patients with colon involvement. SES-CD was the only independent risk factor of high FC levels.