P105 Evaluating the frequency of MEFV gene mutation and its impact on the clinical course in patient with inflammatory bowel disease
S.S. Kocaöz1, B. Ünsal*2, Z. Akpinar2, D. Güleç1, A.H. Ihtiyar1, E.S. Yuksel2, C. Çekiç2
1Bozyaka Training and Research Hospital, Biochemistry, Izmir, Turkey, 2Katip Çelebi University Ataturk Training and Research Hospital, Gastroenterology, Izmir, Turkey
Inflammatory bowel disease (IBD) and familial mediterranean fever (FMF) have similar clinic and pathologic features. Here in the frequency of MEFV gene mutation and the effect of its presence on the outcome of IBD was evaluated.
Genetic variants on 2nd and 10th exon of MEFV gene were determined by DNA sequence analysis in blood samples of IBD patients. The relation between presence of MEFV gene mutation and the requirement of steroid, immunomodulator, biologics and surgical intervention was analyzed.
Hundred IBD patients (55 ulcerative colitis and 45 Crohn's disease) were evaluated. The frequency of MEVF gene mutation was 20% (n=20). Although no relation was found between the presence of MEFV gene mutation and the requirement of steroid (p=0.917), immunomodulator (p=0.468) and biologic agent (p=0.585), there was a statistically significant relation between the need for surgery (p=0.021). In logistic regression analysis the presence of E148Q and M694V mutations were associated with the requirement of surgical intervention [Odds ratio, 6,25 (95% CI, 1.1-34.6)].
It was determined that the mutation related to FMF in the MEVF gene encoding substances important in inflammatory function, was high in IBD patients that required surgery. Given the fact that these patients have frequent and severe attacks it should be confirmed whether the mutations are related to the clinical severity.