Search in the Abstract Database

Search Abstracts 2015

* = Presenting author

P107 Increased prevalence of lower GI tract abnormalities without any IBD in patients with primary biliary cirrhosis

M. Basaranoglu*1, 2, M. Yuksel3, O. Coskun3, M. Kaplan2, A. Aksoy2, Z. Bilge2, N. Turhan4, M. Ozdemir5

1Bezmialem University, Gastroenterology, Istanbul, Turkey, 2Türkiye Yuksek Ihtisas Hospital, Gastroenterology, Ankara, Turkey, 3Türkiye Yüksek Ihtisas, Gastroenterology, Ankara, Turkey, 4Türkiye Yuksek Ihtisas Hospital, Pathology, Ankara, Turkey, 5Türkiye Yuksek Ihtisas Hospital, Radiology, Ankara, Turkey

Background

Involvement of lower gastrointestinal (GI) tract, particularly inflammatory bowel disease (IBD) prevalence, is not known in patients with primary biliary cirrhosis (PBC). Our aim was to evaluate these involvements in patients with PBC by using lower GI tract endoscopy. Because of both diseases (IBD and PBC), have similar background, the occurence of IBD was also questioned by endoscopy with/or without biopsy.

Methods

We evaluated our PBC clinic's records, retrospectively. Lower GI tract abnormalities were evaluated by colonoscopy and rectoscopy. Patients with recent onset dyspepsia were used as a control group.

Results

Of the 82 patients with PBC, 62 had documented abdominal ultrasound and 18 patients had lower GI tract endoscopy Results. There were 61 patients without PBC as a control group. All of the patients, 8.1% in PBC and 8.1% in control were male (p> 0.05). Lower GI tract examination was performed by colonoscopy with ileum entubation (IE) in 5 patients and without IE in 8 patients as rectoscopy was in 5 patients. Colon polyps (size from 1 to 15 mm) were found in 5 patients as follows: 3 with adenomatous, 1 with tubulovillous and 1 with inflammatory changes. Ileum biopsies showed normal ileum mucosa in all 5 patients. US showed: Gallbladder polip, 1.6% in PBC vs 4.9% in controls (p> 0.05); gallbladder sludge&stone, 14.5% in PBC vs 9.8% in controls (p> 0.05); gallbladder operation, 22.6% in PBC vs 9.8% in controls (p= 0.05); gallbladder wall tickness, 6.5% in PBC vs 1.6% in controls (p> 0.05); all gallbladder abnormalities 43.5% in PBC vs 26.2% in controls (p< 0.05); pancreas abnormalities 6.5% in PBC vs 0% in controls (p< 0.05).

Conclusion

Our Results showed that colon adenomatous polyps occurence was increased in PBC. None of the patients with PBC had IBD.