P108 Mean Platelet Volume As An Inflammatory Marker In Inflammatory Bowel Disease
Y. Alahdab*1, K. Abacar2, G. Karakaya2, A. Ozdemir2
1Fatih Sultan Mehmet Egitim Arastirma Hastanesi, Gastroenterology, Istanbul, Turkey, 2Fatih Sultan Mehmet Egitim Arastirma Hastanesi, Internal Medicine, Istanbul, Turkey
Many non-invasive tests have been studied for diagnosis and determining the activation degree of inflammatory bowel disease (IBD). Thrombocyte count and mean platelet volume (MPV) are influenced by the chronic inflammation. They are considered as useful markers of inflammatory bowel disease. The aim of the study was to investigate the capacity of MPV and other inflammatory markers in detecting IBD activity and also to determine whether MPV would be a useful, cheap and non-invasive biomarker for following up and determining severity of IBD.
A total of 181 patients with IBD (128 ulcerative colitis and 53 Crohn's disease) and 30 healthy volunteers were enrolled into the study. Disease activity was assessed using the Crohn's Disease Activity Index (CDAI) and the Truelove and Witts severity index. Platelet counts, MPV, and inflammatory parameters were measured for all study subjects.
Eighty-one subjects had active disease and 100 subjects were in clinical remission. Total platelet count (PLT), sedimentation rate, and C- reactive protein (CRP) were significantly increased (p=0.001) and mean platelet volume was significantly reduced (p=0.015) during the clinical relapse state compared to the clinical remission state. The significant difference of MPV values was most apparent between remission and severe disease states (p=0.004). Statistical difference was not found between moderate or mild disease activity and remission state in terms of MPV values. A statistically significant decrease in MPV was noted in patients with severely active disease (8.24 ± 0.61 fL) compared with healthy controls (7.43 ± 1.07 fL) (p=0.013; p<0.05).
Our study showed that MPV is reduced in IBD, particularly in patients with severely active disease. Decreased MPV can be an independent laboratory marker of clinical disease activity in IBD.