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P111 Are extraintestinal manifestations associated with disease outcomes in Ulcerative Colitis? Results from a population-based inception cohort between 2002-2012

P.A. Golovics*1, B. Lovasz1, Z. Vegh1, I. Szita2, M. Balogh3, S. Vavricka4, G. Rogler4, L. Lakatos2, P. Lakatos1

1Semmelweis University, 1st Department of Medicine, Budapest, Hungary, 2Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, 3Grof Eszterhazy Hospital, Department of Medicine, Papa, H`ungary, 4University Hospital Zurich, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Zurich, Switzerland

Background

Association between extraintestinal manifestation (EIM) and disease activity suggest a common pathogenetic link. Limited data are available on the prevalence of extraintestinal manifestation and the association with the disease outcome. The aim of this study was to analyze prospectively the association between EIMs (joint, skin, occular), treatment strategy and long-term disease outcomes in the population-based UC inception cohort from Veszprem province between 2002 and 2012.

Methods

Data of 347 incident UC patients diagnosed between January 1, 2002 and December 31, 2010 were analyzed (m/f: 200/147, median age at diagnosis: 36, IQR: 26-50 years, duration: 7, IQR 4-10 years). Both in- and outpatient records were collected and comprehensively reviewed.

Results

EIMs (joint, skin, ocular) were present in 17.3%. There was an association between the presence and number of EIMs and young age at onset (p=0.03 OR: 1.77, 95%CI: 1.00-3.08), disease extent (pextensive=0.003 OR: 3.58, 95%CI: 1.37-9.30) and female gender (p=0.07, OR: 1.57 95%CI: 0.90-2.77), but not with smoking and colectomy. Presence of EIMs was associated with need for steroids (p<0.001, OR: 3.1, 95%CI: 1.74-5.51) and azathioprine (p=0.004, OR: 2.57, 95%CI: 1.35-4.89) in both univariate and logistic regression analysis. In Kaplan-Meier analysis there was an association between the presence of EIMs and time to first IBD-related hospitalization (p=0.002). (Image1.)

 

ECCOJC jju027 P111 F0001

“Figure 1. Cumulative probability of first IBD-related hospitalisation”

 

Conclusion

Presence of EIMs in UC was associated with the treatment steps and need for hospitalization.