P167 Prolonged Small Intestinal Transit in Crohn's Disease is associated with a history of stricturing and penetrating disease.
A.-M. Haase*, L. Schoesler, L. Ambrosius Christensen, J. Agnholt, J.F. Dahlerup, K. Krogh
Aarhus University Hospital, Department of Hepatology and Gastroenterology , Aarhus, Denmark
Gastrointestinal motor disorders may complicate Crohn's disease (CD) and make clinical evaluation difficult. In spite of this, little is known about gastrointestinal motor disorders in CD. Moreover, it is not clear which clinical characteristics of CD are associated with abnormal transit patterns. This is relevant to the clinician, especially when symptoms are present in otherwise quiescent CD. Our aim was to investigate which clinical characteristics of CD are associated with abnormal small intestinal transit time (SITT).
This retrospective study includes data from capsule endoscopy examinations and medical reports of 118 patients with CD and 43 controls without CD performed at Aarhus University Hospital, Denmark from 2002 to 2011. Cases with capsule retention were excluded. Data were analysed using regression models.
Gastric emptying (GE) and SITT did not differ between patients with CD (median GE: 27 min (range 1 - 592), SITT 295 min (range 78 - 481)) and controls (median GE: 16 min (range 1 - 138), SITT 285 min (range 114 - 481)). Among patients with CD, prolonged SITT was associated with stricturing (p = 0.012) and penetrating disease behaviour (p = 0.003). No statistically significant difference was found between stricturing and penetrating disease (p = 0.51). Age, gender, duration of disease, smoking, disease localization, active disease, level of faecal calprotectin, and specific findings on capsule endoscopy were not associated with significant changes in SITT.
This study indicates that prolonged SITT is associated with the behaviour or phenotype of CD. Furthermore, our findings imply that changes in small intestinal motility causing prolonged SITT are chronic rather than a transitory phenomenon since disease location and signs of inflammation present at the time of CE did not significantly affect SITT.