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* = Presenting author

P194 The Assessment of Disease Activity by Quantitative Fecal Immunochemical Test in Ulcerative Colitis

H.W. Kim, S.B. Park*, C.W. Choi, D.H. Kang, G.A. Song

Pusan National University Yangsan Hospital, Internal Medicine, Yangsan, South Korea

Background

Ulcerative colitis (UC) is a chronic inflammatory bowel disease. The assessment of inflammation performed by invasive colonoscopy. Fecal calprotectin seems to be alternative nowadays, and quantitative fecal immunochemical test (FIT) could potentially be used as a marker for mucosal inflammation. We evaluated the efficacy of quantitative FIT as biomarker for endoscopic inflammation in patients with UC.

Methods

Collected feces were examined quantative fecal blood with automated equipment. Endoscopic disease severity were assessed using the Mayo endoscopic subscore classification, and extent of disease were grouped by proctitis, left-side colitis and pancolitis. Clinical activity were classified by remission or active.

Results

A total of 82 FIT Results in conjunction with colonoscopies were evaluated in 63 UC patients. Colonoscopy findings revealed that endoscopic subscore was Mayo 0 in 21 (25.6%), Mayo 1 in 39 (47.6%), Mayo 2 in 15 (18.3%), and Mayo 3 in 7 (8.5%). Extent of disease was proctitis in 20 (24.4%), left-side colitis in 30 (36.6%) and pancolitis in 32 (39.0%). All of patients with a Mayo 0 endoscopic subscore had no hemoglobin (negative FIT, 0 ng/ml). Quantitative FIT was statistically significant positively correlated with endoscopic activity (r = 0.626, P < 0.01 ) and clinical remission (r = 0.496, P < 0.01 ). But quantitative FIT was not correlated with extent of disease (r = - 0.047, P = 0.676 ).

Conclusion

Qauntitative FIT can use as less invasive and economic biomarker for the presence of endoscopic inflammation in UC patients, although we do not know the extent of disease.