P233 Risk factors and clinical signicance of endoscopic entent progression in patients with Ulcerative Colitis
Y.-f. Li1, R. Mao*2, B.-l. Chen2, Y. He2, Z.-r. Zeng2, M.-h. Chen2
1Singapore General Hospital, Department of Internal Medicine, Singapore, Singapore, 2First Affiliated Hospital of Sun Yat-Sen University, Department of Gastroenterology, Guangzhou, China
Ulcerative colitis (UC) may extend in a proximal and continuous fashion to involve varying bowel segments. However, the risk factors predictive of proximal extension and clinical outcome of extent progression have yet to be determined. The aim of this study was to identify risk factors predictive of subsequent extent progression in UC patients and to evaluate the clinical outcome of these patients.
We retrospectively analyzed 518 UC patients including proctitis , left-sided colitis and entensive colitis without ascending colond involvement at the time of diagnosis who were regularly followed and underwent colonoscopy between 2003 and 2013.
A total of 87 (16.8%) patients experienced proximal disease extension. The median time of extent extension was 40.3 months（IQR: 8.3-42.2). Independent factors associated with proximal disease extension was steroid dependency during the course (p=0.032). In addition, proximal disease extension was associated with disease relapse and use of immunosuppresive agents (p=0.025 and p=0.000 ).
Steroid dependency in the disease course was associated with a higher probability of proximal disease extension during the follow-up period. Moreover, those with disease extension were more likely to experience relapse and use of immunosuppresive agents, indicating poor prognosis.