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* = Presenting author

P276 Evaluation of histological parameters in patients with clinical remission of ulcerative colitis

E. Kondrashina*1, O. Schukina1, A. Kharitidis2, A. Botina3, E. Markova2

1North-Western state medical university named after I.I. Mechnikov, Department of Gastroenterology and Dietology, St-Petersburg, Russian Federation, 2City clinical hospital №31, St-Petersburg, Russian Federation, 3The First Pavlov State Medical University of St. Peterburg, Department of Patologic Anatomy, St-Petersburg, Russian Federation

Background

Clinical remission and endoscopic mucosal healing are important endpoints in management of ulcerative colitis (UC). But even in asymptomatic patients with healed mucosa, a variety of histological patterns can be found in the large bowel mucosa. The goal of the study was to examine histological changes in the mucosa of patients with clinical remission of UC and compare them.

Methods

25 patients with clinical remission of UC underwent fibrocolonoscopy with biopsy (ascendum, descendum and rectum) and histological assessment of disease activity on the Gebos scale. Due to limited number of observations, it was possible to identify comparable study and control groups only for two parameters: increased eosinophil count and increased density of the cellular infiltrate in the mucosa. In the study group studied parameter was present, and in the control group did not.

Results

Erosions, cryptitis, hyperplasia of lymphoid structures and infiltration of the intestinal mucosa with neutrophilic leukocyte often observed in the presence of increased eosinophil count in the mucosa and/or increased density of the cellular infiltrate. Our Results are shown in Table 1 and Table 2.

Table 1 The frequency of other histological changes in a group with an increased eosinophil count in the mucosa

ECCOJC jju027 P276 F0001

 

 

Table 2 The frequency of other histological changes in a group with an increased density of the cellular infiltrate in the mucosa

ECCOJC jju027 P276 F0002

 

Conclusion

Increased eosinophil count and/or increased density of the cellular infiltrate in the mucosa often accompanied by other signs of lack of the mucosa healing. Confirmation of complete remission of UC requires histological control for exclusion of the inflammation signs.