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* = Presenting author

P286 Prevalence of Ulcerative Colitis and Crohn ileocolitis in patients with celiac disease

M. Basaranoglu*1, 2, M. Yuksel3, O. Coskun3, A. Aksoy2, M. Kaplan2, Z. Bilge2, N. Turhan4, M. Akdogan2, M. Ozdemir5

1Bezmialem University, Gastroenterology, Istanbul, Turkey, 2Türkiye Yuksek Ihtisas Hospital, Gastroenterology, Ankara, Turkey, 3Türkiye Yüksek Ihtisas, Gastroenterology, Ankara, Turkey, 4Türkiye Yuksek Ihtisas Hospital, Pathology, Ankara, Turkey, 5Türkiye Yuksek Ihtisas Hospital, Radiology, Ankara, Turkey

Background

It was reported that involvement of lower gastrointestinal (GI) tract is rare in patients with celiac disease. Because of both diseases, inflammatory bowel disease (IBD) and celiac disease, have a similar autoimmune background, the occurence of IBD was questioned by lower GI endoscopy with biopsy in this study. Our aim was to evaluate IBD in patients with celiac disease.

Methods

We evaluated our celiac disease clinic records, retrospectively. Lower GI tract abnormalities were evaluated by colonoscopy, rectoscopy and/or double balloon enteroscopy (DBE).

Results

Of the 198 patients with celiac disease, 36 had documented lower GI tract endoscopic examination Results. Lower GI tract examination was performed by colonoscopy with ileum entubation (IE) and biopsy in 18 patients, rectoscopy in 17 patients and in one patient with DBE. Of the 36 patients with celiac disease, 5 patients had IBD (14%). Of the 4 patients with ulcerative colitis diagnosed, 2 had moderate or severe active pancolitis. The other two patient had left-side ulcerative colitis. One patient had crohn ileitis which was diagnosed by IE and ileum biopsy. We also found colon polyps in 6 patients (17%). These polyps showed adenomatous, tubulovillous or inflammatory changes with the size from 1 mm to 50 mm. Five of them had multiple polyps.

Conclusion

Our Results showed that patients with celiac disease may have IBD, even severely active ulcerative pancolitis or Crohn ileitis. So, we recommend a lower GI tract examination with deep IE and ileal and colonic biopsies in patients with celiac disease to early diagnosis of IBD.