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P370 IBD-Control Questionnaire: validation and evaluation in clinical practice

I. Ribeiro*1, C. Fernandes2, J. Silva2, A. Ponte2, J. Carvalho2

1Hospital Center of Vila Nova Gaia, Gastroenterology Department, Vila Nova Gaia, Portugal, 2Centro Hospitalar de Gaia/Espinho, Gastroenterology, Gaia, Portugal

Background

The use of patient-reported outcome measures in clinical practice is increasingly advocated as a mean of supporting patient-centered care, informing decisions and driving service quality. IBD-Control Questionnaire has been recently developed and it is intended to measure overall disease control from the patient's perspective in the last 2 weeks1. We aimed to validate IBD-Control questionnaire in our clinical practice, namely its subscores IBD-Control-8 and IBD-Control-VAS.

1 - Bodger K et al. Gut 2013;0:1-11

Methods

A single-center, blinded, prospective study evaluating consecutive patients in an outpatient basis during September to November 2014. IBD-Control questionnaire was completed by each patient prior to medical evaluation. Then, two trained physicians blinded to the questionnaires, recorded activity indices (Harvey-Bradshaw index - HBI, Simple Clinical Colitis Activity index - SCCAI, Montreal Classification), Global Physician assessment and protein C-reactive (PCR) value. Inactive disease was defined by disease activity indices within reported remission ranges (HBI< 5, Montreal classification S0). For IBD-Control-8, a cut-off of >=13 points and for IBD-Control-VAS a cut-off of >=85 points were used to identified patients with quiescent IBD.

Statistical tests: spearman test,X2.

Results

77 consecutive IBD-patients were evaluated, from which 53 with Crohn's disease and 24 with Ulcerative Colitis. Mean age: 43.3 years (±14.4); Female gender: 53.2%. Mean scores: IBD-Control-8 (range 0-16) 13.2 (±3.7), and IBD-Control-VAS (range 0-100): 81.2 (±17.8).

Strong correlation between IBD-Control-8 and IBD-Control-VAS (r=0.71, p<0,001). Moderate-to-strong correlations between IBD-Control-8 and: HB index (r= -0.58), SCCAI (r= -0.60), Montreal classification (r= -0,66) and Global Physician assessment (r= -0.70). IBD-Control-VAS achieved similar Results (HBI: r=-0.57; SCCAI: r=-0.42; Montreal classification: r=-0.50; Global physician assessment: r= 0.65; p< 0.001 for all Results). Weak correlation between IBD-Control-8 and IBD-Control-VAS with PCR value (r= -0.16 and r= -0,23, respectively).

IBD-Control-8, with a cut-off of >=13 points and IBD-Control-VAS with a cut-off of >=85 points were both significatively associated with inactive IBD (p<0.001, for each score).

Conclusion

IBD-Control-questionnaire revealed a moderate-to-strong correlation with Harvey-Bradshaw index, Simple Clinical Colitis Activity index, Montreal classification and Global Physician assessment, and a poor correlation with PCR value. IBD-Control questionnaire may be valuable in clinical practice, mainly for an accurate non-onsite evaluation of IBD-patients.