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P394 Prevalence of malnutrition in patients with Inflammatory Bowel Disease - a Romanian National Register based study

M. Ispas*1, A. Lupu1, L. Gheorghe1, D. Dobru2, A. Tantau3, A. Goldis4, M. Ilie5, C. Gheorghe1, M. Ciocirlan1, C. Cijevschi6, C. Mihai6, R. Iacob1, M. Diculescu1

1Fundeni Clinical Institute, Gastroenterology, Bucharest, Romania, 2Municipal Hospital Targu Mures, Gastroenterology, Targu Mures, Romania, 33rd Medical Clinic Cluj-Napoca, Gastroenterology, Cluj-Napoca, Romania, 4University of Medicine ‘Victor Babes’, Clinic of Gastroenterology, Timisoara, Romania, 5Floreasca Emergency Hospital, Gastroenterology, Bucharest, Romania, 6Gastroenterology and Hepatology Institute , Gastroenterology, Iasi, Romania


Malnutrition may be associated in patients with inflammatory bowel diseases (IBD). It is multifactorial (inadequate intake, inflammation, malabsorption, therapy related) and may worsen disease prognosis. The aim of this study was to assess the prevalence of malnutrition in IBD patients.


We analyzed available data from 614 patients registered in the IBDProspect multicenter national registry in the last 5 years. We defined malnutrition as involuntary weight loss during the previous 3 months, mild when less than < 5% and moderate-severe when more >=5% of initial weight.


Malnutrition was found in 30.1% of patients (10% mild and 20% moderate-severe), with a mean age of 40 ± 17.9 years. There were no differences between age, gender or smoking status groups. Prevalence of malnutrition increased with disease activity. For Crohn's disease (CD), malnutrition was associated with the presence of intraabdominal fistulas, abscesses or intestinal bleeding (p=0.036) and was marginally statistically significant more frequent in patients with ileo-colonic extension (p=0.053). In ulcerative colitis (UC) patients, prevalence of malnutrition was significantly lower in proctitis than more extensive disease (p=0.004). Association of anemia was significantly higher in malnourished CD (p<0.0001) and UC (p<0.002) patients. Malnutrition was significantly more frequent in patients treated with steroids (p<0.0001), independent of disease phenotype or extension; but there was no difference in patients treated with aminosalicylates, immunosuppressants or anti- TNF.


Nutritional assessment should be performed in all IBD patients as its prevalence is higher in active, more extensive or steroid treated disease.