P425 Endothelial function and cardiovascular risk in Inflammatory Bowel Disease in remission phase
L. Montenegro*, G. Losurdo, A. Zito, M.M. Ciccone, E. Ierardi, A. Di Leo, M. PRINCIPI
University of Bari, DETO, Bari, Italy
Endothelial dysfunction has been reported in patients affected by inflammatory bowel diseases (IBD) in active phase, but not yet in remission.
We evaluated endothelial dysfunction by brachial artery flow-mediated vasodilatation (FMD), and subclinical atherosclerosis by assessment of common carotid intima-media thickness (CCA-IMT) in a cohort of patients with Crohn's disease (CD) or Ulcerative colitis (UC) in remission phase compared to healthy control subjects. The remission was evaluated by Crohn's disease activity index (CDAI) for CD and Mayo score for UC. ANOVA was performed to compare continuous variables and Pearson's r coefficient was calculated for correlation between disease activity and FMD or IMT.
Fifty-eight patients with IBD were enrolled (29 males, aging 40 ± 15, 16 CD and 15 UC) and 40 healthy controls (16 males, aging 45 ± 15). FMD values for IBD in remission was similar to control group (8.38 ± 1.75 vs 9.39 ± 2.23; p=ns). No statistically significant difference was detected between CD (8.38 ± 1.75) and UC (9.64 ± 5.49). No statistically significant difference was found after adjustment for age, sex, body mass index, and family history of cardiovascular disease. Finally, no differences in IMT values between IBD in remission and control group was found, while significant inverse relationship between C reactive protein (CRP) and FMD was detected (r=-0.876; p <0.005).
IBD in remission revealed FMD values comparable to non-IBD population. CRP inversely correlates with FMD. Therefore, endothelial function is completely normalized during remission phase and this suggests the possibility of the reversal/arrest of atherosclerotic process.