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P442 Outcome of early surgery versus aggresive medical therapy in patients with newly diagnosed limited inflammatory/obstructive (A2/3L1B1/2) terminal Ileitis: A two-year, prospective, single-center, pilot study

G. Mantzaris*1, K. Papamichael1, I. Papakonstantinou2, D. Magganas3, I. Kalogeropoulos4, E. Archavlis1, A. Christidou1, H. Vienna1, N. Kyriakos1, X. Tzannetakou1, I. Internos1, S. Anastasiadis1, P. Karatzas1, L. Varytimiadis1

1Evangelismos Hospital, Gastroenterology Department, Athens, Greece, 2Aretaeion Hospital, B' Department of Surgery, Athens, Greece, 3Evangelismos Hospital, A' Department Of Surgery, Athens, Greece, 4Evangelismos Hospital, Radiology Department, Athens, Greece


Background: Data are scarce regarding the outcome of 'curative' early surgery (ES) versus 'aggressive medical therapy' [AMT, azathioprine (AZA) and anti-TNF biologics] for limited mixed inflammatory-obstructive Crohn's terminal ileitis (LMI/OTI). EST achieves removal of the affected segment and induces prolonged remission reserving immunosuppressives for patients at high-risk for recurrence. AMT can induce and maintain remission of CD but may be associated with serious adverse events and cannot guarantee long-term avoidance of surgery. Aim: To assess prospectively in a single-center pilot study the 2-year outcome of EST vs AMT in consecutive patients with LMI/OTI (phenotype A2/3L1B1/2).


Eligible were patients with newly diagnosed active (CDAI>180) LMI/OTI CD (despite treatment with 9mg/d budesonide for 6-8 weeks) and at high-risk for post-operative recurrence. LMI/OTI was defined as the combination of: a) raised inflammatory indices (leukocytes, platelets, CRP), b) involvement of < 25cm terminal ileum, characterized by a narrow lumen, ulcerated but slightly distensible bowel wall with pre-stenotic dilatation although not purely stricturing disease at enteroclysis or MRI enterography, and c) inability to pass the colonoscope to the proximal unaffected ileum. After a thorough discussion, enrolled patients opted for AMT or EST (laparoscopic or open). EST patients received AZA (2.5mg/kg) for post-operative prophylaxis starting 14 days after surgery. AMT patients received standard doses of AZA and anti-TNF agents. Patients were followed for 2 years by physical examination and laboratory tests at bimonthly visits. Endoscopy was performed at 6, 12, and 24 months. Primary end-points were endoscopic remission (Rutgeerts score < or =1) for EST and avoidance of surgery for AMT.


Between 2007 and 2011, 17 patients [7M:10F, mean age 24(18-67) years, 12 smokers] consented to undergo EST and 17 patients [8M:9F, age 26(17-68) years, 13 smokers] received AMT. 2 years after EST, 3/17 (18%) patients had endoscopic recurrence and switched to biologics; 82% patients were in endoscopic remission. On AMT, 10/17 (59%) patients underwent surgery for complications (bowel obstruction and/or abscess, n=5), lack of efficacy (n=3) or adverse events to therapy (n=2); seven patients were in clinical remission (3 in deep remission).


In this pilot study in consecutive CD patients selected by the A2/3L1B1/2 phenotype, EST appears to offer a better 2-year outcome than AMT. However, decisions should be taken on a case-to-case basis considering patient's age, life expectations, disease activity, relative degree of obstruction vs inflammation, and treatment morbidity. Large prospective trials are needed to evaluate longer-term outcomes.