P445 Significance of non-alchoholic fatty liver disease in patients with Crohn's disease.
Hiroshima University,, Department of Medicine and Molecular Science,, Hiroshima, Japan
As reported by published studies, non-alcoholic fatty liver disease (NAFLD) has recently increased in Crohn's disease (CD). There are, however, no studies evaluating the significance on NAFLD in CD. This study demonstrates the frequency and impact of NAFLD on the disease course of CD.
CD patients who underwent abdominal ultrasound (US) from November 2008 to October 2014 were analyzed. CD patients with NAFLD by US were compared with those who had no evidence of NAFLD.
This single center cross-sectional study included 300 CD patients with US; 65 (21.8%) had evidence of NAFLD by US imaging. The NAFLD group had lower CRP (0.58 vs. 2.18 (mg/dl), P < 0.0001) and significant higher remission (CDAI < 150) rate (75.9% vs. 53.7%, P = 0.0024). Age (42.0 vs. 35.5, P=0.0001) and body mass index (21.7 vs. 19.8, P < 0.0001) was higher and disease duration was longer (17.2 vs. 14.1 (years), P = 0.028) in NAFLD group. The effects of sex did not differ between groups. Multivariable analysis showed that NAFLD was an independent predictor of CRP negative (< 0.3mg/dl)(odds ratio (OR) 1.85; 95% confidence interval (CI) 1.03-3.37) and CDAI remission (OR 2.24; 95% CI 1.12-4.68).
NAFLD occurred in 21.8% of the CD population. NAFLD patients were in relatively better prognosis than those without NAFLD in CD course.