P506 Predictors of Health-related Quality of Life in Asian Patients with Inflammatory Bowel Disease: Psychological, Clinical and Demographic factors
X.-p. Luo*, R. Mao, Y. He, B.-l. Chen, Z.-r. Zeng, M.-h. Chen
First Affiliated Hospital of Sun Yat-Sen University, Department of Gastroenterology, Guangzhou, China
An impaired health-related quality of life(HRQOL) has been demonstrated in patients with inflammatory bowel disease(IBD). The factors associated with decreased HRQOL have not been fully known, specially the psychological factors. In this study, we aim to identify the predictors of HRQOL in a Chinese population of IBD patients.
We conducted a cross-sectional, prospective study of patients presenting to our tertiary care IBD center. A total of 219 patients with IBD were recruited into the study. HRQOL was measured using the 36-Item Short-Form Health Survey (SF-36) and Inflammatory Bowel Disease Questionnaire (IBDQ). Anxiety and depression were assessed by the Hospital Anxiety and Depression Scale (HADS). Perceived stress and perceived social support were also assessed by standardized scales. Clinical and demographic data were obtained from our database and the electronic medical records . Univariate analyses and multiple linear regression analysis were performed to identify predictors associated with HRQOL.
91.3%(200/219) of patients included completed the questionnaires. The prevalence of anxiety and depression in our study population were 24%(48/200) and 16%(32/200). Univariate analyses showed that anxiety symptoms, depression symptoms , perceived stress , perceived social support ,disease activity , previous hospitalizations and relapses, hemoglobin and medical costs were strongly or moderatly correlated with HRQOL. Multivariate regression analysis revealed that both disease activity and anxiety symptoms were strong predictors of impaired HRQOL.
Our study demonstrates that psychological disorder contributes to impaired HRQOL in IBD, independent of the disease activity. Therefore, psychological distress should be considered in our current management of IBD patients and appropriate psychotherapy may improve HRQOL of these individuals.