P565 The Increased Prevalence of Non-Alcoholic Fatty Liver Disease in Inflammatory Bowel Disease Patients is not Related To Inflammatory Load
Y. Erzin1, N. Demir1, C. Cabuk1, F. Kantarci2, I. Hatemi*1, A.F. Celik1
1Istanbul University Cerrahpasa Medical Faculty, Gastroenterology, Istanbul, Turkey, 2Istanbul University Cerrahpasa Medical Faculty, Internal Medicine, Istanbul, Turkey
Aim of the study was to compare the prevalence of non-alcoholic fatty liver disease (NAFLD) between patients with IBD and IBS and determine its predictors among IBD patients.
In this cross-sectional study IBD and IBS patients' charts were reviewed in a retrospective manner. 276 IBD patients (172 UC and 104 CD) and 161 age and sex adjusted IBS patients were compared regarding the prevalence of NAFLD using abdominal USG. Age at disease onset, at USG, sex, disease duration, location, and behavior, alcohol-steroid use, and complete blood count, blood levels of fasting lipids, glucose, and acute phase reactants and body mass index (BMI) at the time of USG were noted.
None of the subjects had alcohol use more than 20 g/d. The IBD patients' mean age±SD at USG was 44.39 ± 14.14 yr.(52% being female), and of IBS patients 44.11 ± 13.73 yr.(54% being female). Patients in both groups had similar BMI values. The prevalence of NAFLD among IBD patients was significantly higher compared to those with IBS [(36.2% vs. 25.5%, respectively; χ ² =5.393, p=0.02); OR: 1.663 (95%CI: 1.08 -2.56)]. There were 100 patients with NAFLD in 276 IBD (33.1% in UC, 41.3% in CD; NS) patients. IBD patients with NAFLD had significantly higher albumin, TG, LDL, glucose, hct, MCV, BMI values and significantly lower ESR compared to those without NAFLD. Besides these disease location, extension, behavior, steroid use, and CRP levels at the time of USG did not show any significant difference (Table 1). Cox-regression analysis disclosed higher glucose (p=0.003) and lower ESR (p=0.042) to be the only independent predictors of NAFLD.
“Table 1. Comparison of IBD patients with or without NAFLD.”
In this cross-sectional study the prevalence of NAFLD is higher among IBD compared to age-and sex adjusted IBS patients with similar BMI values. The fact that IBD-NAFLD patients had significantly higher levels of albumin, TG, LDL, glucose, hct, MCV, BMI values and significantly lower ESR compared to those without NAFLD points to nutritional facts rather than inflammatory load in the development of NAFLD in IBD.