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P589 Change in clinical features of Korean Crohn's Disease patients following the introduction of an anti-TNF-alpha agent: Results from the CONNECT study

Y.S. Kim*1, S.I. Bae1, B.D. Ye2, J.P. Im3, J.W. Kim3, J.S. Kim3, J.H. Cheon4, Y.-H. Kim5, D.S. Han6, W.H. Kim4, C.H. Yang7

1Inje University College of Medicine, Internal Medicine, Seoul, Korea, Republic of, 2University of Ulsan College of Medicine, Internal Medicine, Seoul, Korea, Republic of, 3Seoul National University College of Medicine, Internal Medicine, Seoul, Korea, Republic of, 4Yonsei University College of Medicine, Internal Medicine, Seoul, Korea, Republic of, 5Sungkyunkwan University School of Medicine, Internal Medicine, Seoul, Korea, Republic of, 6Hanyang University Guri Hospital, Gastroenterology, Guri, Korea, Republic of

,

7Dongguk University College of Medicine Gyeongju Hospital, Division of Gastroenterology & Hepatology, Department of Internal Medicine, Gyeongju, Korea

Background

Background: Anti-tumor necrosis factor-alpha (anti-TNF-alpha) agents have been known to alter the natural course of Crohn's disease (CD). Therefore, we aimed to compare the changes in clinical features and disease course according to the time of introduction of an anti-TNF-alpha agent in Korea.

Methods

Methods: We performed a retrospective analysis of 1,382 Korean CD patients diagnosed between 1982 and 2008 who were enrolled in the retrospective cohort of the CrOhn's disease cliNical NEtwork and CohorT (CONNECT) study. The anti-TNF-alpha agent was applied to national medical insurance in 2005, and has been more widely used in Korea since 2007. Accordingly, the patients were divided into three groups [Group A (1981-2004): 656 patients; Group B (2005-2006): 282 patients; and Group C (2007-2008): 362 patients].

Results

The average age (p = 0.251), disease location (p = 0.941), and disease behavior (p = 0.813) at the time of diagnosis with CD were not different among the three groups. The anti-TNF-alpha agent was administered to a total of 31.0% of patients (n = 403), which was not different among groups (p = 0.124). However, the 3- and 5-year cumulative probabilities for administering an anti-TNF-alpha agent were significantly higher in group C (p < 0.001). The 3- and 5-year cumulative probabilities of the occurrence of perianal fistula and CD-related surgery were higher in group A than in group C (perianal fistula, p = 0.032; surgery, p = 0.003).

Conclusion

Conclusions: After the introduction of the anti-TNF-alpha agent to the treatment of Korean CD patients, the natural history of CD changed. We found that early administration of an anti-TNF-alpha agent may help delay the occurrence of perianal fistula and the need for surgery in Korean CD patients.