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P649 The incidence of glomerulonephritis in a population-based inception cohort of patients with Inflammatory Bowel Diseases

Z. Vegh*1, B. Lovasz1, P.A. Golovics1, K. Gecse1, E. Macsai2, I. Szita2, M. Balogh3, L. Lakatos2, P. Lakatos1

1Semmelweis University, 1st Department of Medicine, Budapest, Hungary, 2Csolnoky F. Province Hospital, Department of Medicine, Veszprem, Hungary, 3Grof Eszterhazy Hospital, Department of Medicine, Papa, Hungary

Background

Glomerulonephritis (GN) was described to be related to inflammatory bowel diseases (IBD) in some case reports, but only a few data are available on the incidence and prevalence of GN in population-based studies. Our aim was to explore the incidence of GN and its relationship with disease characteristics and medical therapy in a population-based inception cohort of IBD patients in the Veszprem province database between 1977 and 2012.

Methods

A total of 1708 incepted IBD patients were included (male/female: 879/829; CD: 648, age at onset: 29, IQR: 22-39; UC: 1060, age at onset: 36, IQR: 26-50 years) and followed-up until the 31st of December 2012 for a total of 21369 patient-years. Cases with histopathological diagnosis of GN were collected and included in the further analysis.

Results

GN was identified in a total of 6 IBD patients (CD (Crohn's disease)/UC (ulcerative colitis): 5/1, male/female: 5/1, median age at diagnosis: 27.5 (25-39) years). The incidence rate of GN was 0.28 per 1000 patient-years. All patients were administered 5-ASA (5-aminosalicylate) treatment. Total anytime 5-ASA exposure was 88.5 % in CD and 97.5 % in UC. The histopathological types of GN were IgA nephropathia, granulomatous nephritis, membranous glomerulonephritis, mesangio-capillaris glomerulonephritis and mesangio-proliferative glomerulonephritis.

Conclusion

A higher incidence of GN was observed compared to the findings of previous studies. The incidence was higher in males and in CD and a high use of 5-ASA was found.