P678 Childlessness in IBD patients - Analysis of data from the prospective multicentre Swiss IBD Cohort Study
M. Sulz*1, N. Fournier2, L. Biedermann3, G. Rogler3
1Cantonal Hospital St. Gallen, Division of Gastroenterology and Hepatology, St. Gallen, Switzerland, 2Institute of Social and Preventive Medicine, Healthcare Evaluation Unit, Lausanne, Switzerland, 3University Hospital Zurich, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Zurich, Switzerland
The impact of inflammatory bowel disease (IBD) and its treatment on fertility and pregnancy is an important clinical consideration in patients of reproductive age. Overall, the rate of infertility in women with IBD has been reported to vary between 7% and 12%. Main objectives were to analyse the rate of childlessness of female and male IBD patients with unfulfilled wish to conceive within the Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS), one of the largest prospective multicentre IBD cohorts.
We analysed data from the SIBDCS with currently more than 3000 patients with Crohn's disease (CD), ulcerative colitis (UC), or indeterminate colitis (IC), respectively. We included only females with IBD diagnosed at the age <35 years and with age at enrolment <45 years (limitation of childbearing age), with at least two-year follow-up. Also, childless males who actively tried to conceive were analysed by means of descriptive statistics.
As of August 2014, a total of 1412 females were included into the SIBDC (843 CD, 539 UC, 30 IC), with 629 female patients (386 CD, 227 UC, 16 IC) fulfilling inclusion criteria. 266/629 (42%) females had either given birth to at least one child, or were pregnant at last follow-up. There were 363 (58%) females without any children. Of those, 122 childless females have at least once reported to actively have tried to conceive. 74/122 (39 CD; 35 UC/IC) completed at least one follow-up (Table 1). In our cohort, 11.7% of females with IBD (10.1% of CD, 14.4% UC/IC) at childbearing age who were diagnosed with IBD <35 years, tried to conceive without success during follow-up. Among the subgroup of childless females, 20.4% tried to conceive.
“Table 1: Childless females and males within the SIBDCS who actively tried to conceive.”
Regarding males, 89 patients have at least once mentioned to actively try to conceive. Of those, 62 (36 CD; 26 UC) had available follow-up questionnaires (Table 1). Table 2 shows the Kaplan Meier diagram regarding the probability of the male IBD patient's partner to get pregnant, according to the male patient' s age < 35 vs. >35 years.
“Table 2. Kaplan-Meier failure estimates. Probability of partners of males with IBD of getting pregnant, according to age < 35 vs. > 35 years”
In the SIBDCS nearly 12% of females with IBD in childbearing age and diagnosed with IBD < 35 y, tried to conceive without success during follow-up. This data matches with reported data in IBD literature.