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P686 Clostridium difficile infection in inflammatory bowel disease and non-inflammatory bowel disease patients

O. Stoica1, C. Stanciu2, C. Cojocariu1, A.-M. Singeap1, I. Girleanu1, R. Maxim1, A. Trifan*1

1University of Medicine and Pharmacy "Gr. T Popa ", Iasi, Institute of Gastroenterology and Hepatology, Iasi, Romania, 2Institute of Gastroenterology and Hepatology, Bd. Independentei, no. 1, Gastroenterology and Hepatology, Iasi, Romania

Background

During the last decades the incidence and severity of Clostridium difficile infection (CDI) has increased throughout the world both in general population and in other subgroups like inflammatory bowel disease (IBD) patients. The aim of this study was to investigate the differences between CDI in IBD and non-IBD patients.

Methods

We conducted a case-control study including 78 patients diagnosed with CDI hospitalized at the Institute of Gastroenterology and Hepatology in Iasi, Romania, between January 2012-July 2014. Demographic data and clinical characteristics were reviewed for all patients.

Results

A total of 78 patients were diagnosed with CDI, of whom 26 patients (33.33%) had concomitant IBD. The non-IBD patients were older than the IBD patients (60.92 ± 17.48 vs 50.96 ± 18.16, p=0.022) and co-morbidities were more common in the non-IBD study group (OR=2.22, CI=1.33-3.69; p<0.0001). There was no differences between the two groups regarding previous antibiotic treatment. The use of proton pump inhibitors was more frequent in the IBD patients than in the non-IBD subjects (OR=6.09, CI=2.31-16.04; p<0.0001). The duration of hospital stay was similar in both study groups.

Conclusion

Patients with IBD were significantly younger and with less co-morbidities than the non-IBD patients. IBD itself may be an independent risk factor for CDI in IBD patients.