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P689 Inflammatory Bowel Disease and psychological status: Determinants and social consequences

P. Bertomoro, M. G. Vettorato*, F. Simonetti, L. Dall’angelo, G. Brogiato, A. Rigo, R. D’Incà, G. C. Sturniolo

Policlinico Universitario di Padova, Gastroenterologia, Padova, Italy


High levels of anxiety are reported in inflammatory bowel disease (IBD) and causes could be multiple.

The aim of our study is to evaluated the presence of anxiety and the role of therapy in IBD patients.


From 1/6/2014 to 31/8/2014, 220 consecutive patients (73 affected by Ulcerative colitis (UC) and 147 by Crohn's disease (MC) with mean age of 47 years (range 16-78), in therapy with Anti TNF alfa and immunosuppressor were studied with Visual Analouge Scale (VAS) and State-Trait Anxiety Inventory (STAI) questionnaire. Anxiety was defined when State Anxiety > Trait Anxiety.

Activity inflammatory index (HBI, MTWSI), quality of life (S-IBDQ), work productivity (WPAI) and adherence to therapy (Morisky scale) were valueted to identify the possible determinants for anxiety. 40 peers patients in therapy with mesalazine (24 with CU; 16 with MC) were enrolled in the same period, as controll group.


The 32,4% of patients refered anxiety. In the multivariate analysis the determinants of anxiety for STAI were: single state versus married (50% vs 36%, p= 0.003, OR= 2.21, CI 1.31-3.72) and CU vs MC (45,9% vs 31,7%, p=0.03, OR 1.83, CI 1.08-3.11). The Analouge Scale was correlated only with disease activity (p=0.0005, beta= 1.47) either for UC and MC. Anxiety was correlated directly with a lower WPAI (p=0.0001) and lower S-IBDQ (Correlation coefficient -0,62, p<0.0001), while the adherence wasn't associated with anxiety. (p=0.90). No differences emerged between patients in Anti TNFalfa therapy versus mesalazine either for VAS (p=0.59) and for STAI (p=0.84).


Anxiety is frequent in IBD patients, particurlarly in single, in active disease e in patients with UC. The anxiety isn't affected by the type of therapy, instead quality of life and work productivity are negatively influenced by the psychological status.