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* = Presenting author

P716 Enterohepatic helicobacter species as a potentially causative factor of Inflammatory Bowel Disease: A meta-analysis

Q. Yu*, S. Zhang, L. Li, L. Xiong, K. Chao, B. Zhong, M. Chen

The First Affiliated Hospital of Sun Yat-Sen University, Gastroenterology, Guangzhou, China


Enterohepatic Helicobacter species (EHS) colonized in the intestinal mucosa with some extent of Helicobacter pylori composed the Helicobacter species of gut microbiota, but their association with inflammatory bowel disease (IBD) were controversial with numerous studies. Therefore, we conducted a meta-analysis to examine this association.


Pubmed, Scopus, Cochrane Library, and Web of Science databases and meeting abstracts were searched for relevant studies focused on Helicobacter species in the intestinal specimen from IBD by using PCR technique. Of 2955 records reviewed, 20 promising articles were reviewed in detail. Meta-analysis was performed with Stata12.0.


A total of 14 articles were evaluated in this study, including 11 adult studies and 3 pediatric studies. Accordingly, the overall prevalence of Helicobacter species was relatively higher in patients with IBD than in controls, resulting in a pooled RR of 1.59 (95% CI: 1.12-2.27). Meanwhile, the RRs for adult and pediatric patients with IBD were 1.61 and 1.76 (95% CI: 1.03-2.52, 1.17-2.64), respectively. Compared with the controls, patients with IBD tended to show a much higher prevalence of EHS (RR: 2.10, 95% CI: 1.27-3.46) but not of H. pylori in the intestinal mucosa (RR: 1.25, 95% CI: 0.71-2.20). Additionally, the RRs of EHS in patients with CD (Crohn's disease) and in those with UC (ulcerative colitis) were 1.72 (95% CI: 1.20-2.47) and 3.27 (95% CI: 0.93-11.44), respectively.


In general, EHS were found to be associated with IBD compared with controls, especially in pediatric patients with higher prevalence in CD than UC. More studies are needed to identify the mechanisms of EHS in the microbiological etiology of IBD.