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P204 Ultrasound elastography–derived shear wave velocity helps distinguish acutely inflamed from fibrotic bowel in patients with Crohn’s disease receiving surgery

R. Mao1, Y. Chen2, B. Chen1, Y. He1, X. Xie3, Z. Zeng1, S. Ben-Horin4, M. Chen*1, X. Xie3

1The First Affiliated Hospital, Sun Yat-sen University, Department of Gastroenterology, Guangzhou, China, 2Department of Medical Ultrasonics and Department of Gastroenterology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 3Department of Medical Ultrasonics The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 4Department of Gastroenterology, Sheba Medical Centre & Sackler School of Medicine, Tel Aviv University, Israel, Tel Aviv, Israel

Background

Transcutaneous Shear wave elastography (SWE) is a promising, non-invasive approach for measuring tissue mechanical properties in animal model with Crohn’s disease (CD). The aim of this study was to evaluate the feasibility of this approach applied directly to human subjects with Crohn’ disease (CD) in distinction of acutely inflamed from fibrotic intestine before surgery, using the pathological analysis of surgically resected intestinal lesions as reference standard.

Methods

Thirty-five CD patients who underwent elective bowel resection were examined with SWE within 3 months before surgery were reviewed. The index of this study was Young’s Modulus value of the resected bowel by SWE. Pathological inflammatory and fibrosis scores of the resected diseased bowel were classified into 3 grades of severity.

Results

In all, 35 segments from 35 patients were analysed. The pathological intensity of fibrosis was associated with YM (p = 0.017). The degree of inflammation did not correlate with YM (p = 0.116).

Conclusion

SWE provides a simple and accurate approach of local severity of fibrosis. This imaging technique, directly to human subjects, represents a novel assessment with potential for both diagnosis and monitoring in CD.