P273 Risk factors and clinical outcomes associated with cytomegalovirus colitis in patients with acute severe ulcerative colitis
H.-S. Lee*1, H. J. Lee1, H. Seo2, M. Seo2, E. M. Song2, S. W. Hwang2, S. H. Park2, D.-H. Yang2, K.-J. Kim2, B. D. Ye2, J.-S. Byeon2, S.-J. Myung2, S.-K. Yang2
1Asan Medical Centre, University of Ulsan College of Medicine, Health Screening and Promotion Centre, Seoul, South Korea, 2Asan Medical Centre, University of Ulsan College of Medicine, Department of Gastroenterology, Seoul, South Korea
Cytomegalovirus (CMV) colitis can contribute to an unfavourable outcome of acute severe ulcerative colitis (ASUC). The purpose of our present study was to evaluate the clinical outcomes of ASUC according to CMV status, and identify risk factors for CMV colitis in ASUC patients.
We retrospectively analysed patients with ASUC from 2011 to 2014 according to the criteria of Truelove and Witts. CMV colitis was diagnosed by histopathological and/or immunohistochemical analysis of tissue samples. The risk factors for CMV colitis were investigated, and clinical outcomes were assessed using the rate of rescue therapy and colectomy.
Of 149 patients with ASUC, 50 (33.6%) were diagnosed with CMV colitis. During admission, 16 of 149 patients (10.7%) underwent colectomy: 7 of 50 (14.0%) in the ASUC-CMV group versus 9 of 99 (9.1%) in the ASUC only group (p = 0.364). The need for rescue therapy was 2.28-fold higher in the ASUC-CMV group than in the ASUC only group in multivariate analysis (95% confidence interval [CI], 1.10–4.72). Multivariate analysis also revealed that recent use of high-dose steroids (odds ratio [OR] 3.30; 95% CI, 1.33–8.19) and a higher Mayo score (OR 1.58; 95% CI, 1.05–2.38) were risk factors for CMV colitis.
CMV colitis often occurs in ASUC, particularly in patients who have recently been treated with high-dose steroids and have a higher Mayo score on admission. ASUC patients with CMV colitis appear to have a poorer prognosis, as indicated by the greater need for rescue therapy.