P276 Faecal calprotectin is well correlated with quantitative faecal immunochemical test in ulcerative colitis but not in infectious colitis
H.-S. Kim*1, J. H. Seong1, H. M. Kim1, J. Kim2
1Yonsei University Wonju College of Medicine, Division of Gastroenterology and Hepatology, Wonju, South Korea, 2Yonsei University Wonju College of Medicine, Departments of Laboratory Medicine, Wonju, South Korea
Faecal calprotectin is a calcium binding proteins, located in the neutrophil cytosol. Increased faecal calprotectin is observed in infectious colitis, ulcerative colitis, and Crohn’s disease. The aim of this study is to investigate the association between the faecal calprotectin and disease activity of ulcerative colitis and infectious colitis in Korean patients.
The patients with ulcerative colitis or infectious colitis in Wonju Severance Christian Hospital were enrolled. The faecal calprotectin, faecal immunochemical test and faecal leukocytes were measured from the patients’ stool. The disease activity of ulcerative colitis was measured by partial Mayo index score.
From June 2015 to November 2015, 124 patients with ulcerative colitis and 47 patients with infectious colitis were enrolled, and their mean ages were 46.6 ± 17.2 years and 52.6 ± 22.1 years, respectively. The faecal calprotectin levels were not different between ulcerative colitis and infectious colitis (378.14 ± 598.49 mcg/g vs 559.42 ± 593.47 mcg/g, P = 0.078), although serum white blood cells and C-reactive protein (CRP) were higher in infectious colitis than ulcerative colitis. In ulcerative colitis, faecal calprotectin levels were significantly correlated with CRP (r = 0.445, p < 0.0001), faecal leukocyte (r = 0.491, p = 0.046), faecal immunochemical test (r = 0.561, p < 0.0001), and partial Mayo index score (r = 0.517, p < 0.0001). In infectious colitis, faecal calprotectin levels were significantly correlated with faecal leukocyte (r = 0.539, p = 0.005).
The faecal calprotectin levels were positively correlated with partial Mayo index score in Korean patients with ulcerative colitis. In addition, the faecal calprotectin was associated with CRP, faecal leukocyte, and faecal immunochemical test, and these findings suggest that their combination could predict the faecal calprotectin levels.