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P277 Prediction of Crohn’s disease activity using contrast-enhanced sonography

M. Białecki1, A. Sławińska1, A. Liebert2, M. Kłopocka*2, Z. Serafin1

1Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Department of Radiology and Diagnostic Imaging, Bydgoszcz, Poland, 2Nicolaus Copernicus University in Toruń, Collegium Medicum in Bydgoszcz, Chair of Vascular Diseases and Internal Medicine, Bydgoszcz, Poland

Background

Reports on imaging of active Crohn’s disease (aCD) using contrast-enhanced ultrasound (CEUS) are encouraging. However, there is no widely accepted consensus regarding the enhancement curve measures that should be used for aCD identification. An aim of this study was to evaluate the predictive value of CEUS enhancement parameters to diagnose aCD

Methods

In the study, 45 patients with proven CD were included. CEUS was performer with a linear probe and a single dose of SonoVue (4.8 mL). CEUS parameters were calculated using VueBox postprocessing software. aCD was diagnosed in patients presenting Crohn’s Disease Activity Index (CDAI) of over 150.

Results

The study group included 32 subjects (71%) with aCD, and 13 patients (29%) with inactive disease. CDAI moderately correlated with PE (Peak Enhancement), WiR (Wash-in Rate), and WiPI (Wash-in Perfusion Index). Logistic regression analysis of CEUS parameters found PE as the only independent predictor of aCD (p = 0.0054). PE of > 1053 allowed for diagnosis of aCD with 69% sensitivity and 94% specificity (AUC = 0.79, p = 0.0007)

Conclusion

CEUS allows for a diagnosis of aCD with a moderate sensitivity and high specificity. Amongst available enhancement parameters, PE presents the highest predictive value for aCD.