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* = Presenting author

P394 Psychosexual dysfunction in a cohort of Greek inflammatory bowel disease patients in clinical remission: preliminary results

D. Xanthis*, K. Soufleris, E. Gavalas, P. Anyfanti, G. Chatzinakos, N. Grammatikos, A. Tsimperidis, O. Giouleme

Aristotle University of Thessaloniki, Second Propedeutic Department of Internal Medicine, Thessaloniki, Greece

Background

Inflammatory bowel disease has been consistently associated with impaired mental health and sexual function. We aimed at assessing the prevalence and determinants of psychosexual dysfunction in patients in clinical remission at the time of evaluation of the inflammatory burden of the disease with endoscopy or enterography.

Methods

In total, 69 consecutive patients, aged 42.56 ± 1.55years (range 18–64), 39 female and 30 male, were studied. Patients with Crohn’s disease (48) and ulcerative colitis (21) with a mean duration of disease 10.7 = +-1.02 years were included. Female and male sexual function was evaluated using the Female Sexual Dysfunction Index and the International Index of Erectile Function questionnaire, respectively. The Hamilton Anxiety Scale and the Zung Self-Rating Depression Scale were used to detect presence of anxiety and depression. Disease activity was evaluated clinically and objectively with endoscopy in colitis and enterography in small bowel disease. Top-down treatment was defined as administration of biologic based therapy in the first 6 months of disease.

Results

Sexual dysfunction affected 41.6% of men and 64.7% of women. Anxiety was documented in 27.5%, and depression in 5.8% of patients. Psychosexual dysfunction did not correlate with disease duration, subclinical inflammation, top-down treatment, surgery, extraintestinal manifestations, or perianal disease. Although anxiety and depression correlated with sexual dysfunction in general, this was only statistically significant in the case of male sexual dysfunction and anxiety (r = -0.247, p = 0.04).

Conclusion

Patients with inflammatory bowel disease in clinical remission display significantly impaired psychosexual dysfunction in this initial assessment. Addressing this aspect of health-related quality of life could require interventions beyond control of inflammation