P467 The validation of the Crohn’s and Ulcerative Colitis Questionnaire–12 Plus (CUCQ-12 plus): a short quality-of-life measure for inflammatory bowel disease
S. Shwana*1, L. Alrubaiy1, H. Hutchings2, J. Williams2, A. Protheroe3, K. Mortier4
1Prince Charles Hospital, Gastroenterology, Merthyr Tydfil, United Kingdom, 2College of Medicine, Swansea University, Swansea, United Kingdom, 3Royal College of Physicians,, London, United Kingdom, 4Royal College of Physicians, London, United Arab Emirates
No disease-specific quality-of-life (QoL) measures for inflammatory bowel disease (IBD) are established for use routinely in clinical practice due to being lengthy, time consuming, and not applicable to all patients with IBD.
A shorter form of CUCQ-32 was derived by stepwise regression. Construct validity was carried out using the EuroQol 5 dimensions (EQ5D) questionnaire, Simple Clinical Colitis Activity Index (SCCAI) and the Harvey–Bradshaw Index (HBI). Test-retest analysis was done during the patients’ second follow-up visits.
Using the data from 124 patients, a 12-item questionnaire (CUCQ-12) was developed. Literature review and an expert focus group identified supplementary questions to cover patients with stoma. The validity and reliability of the CUCQ-12 was examined using data from 484 patients with IBD as part of the UK IBD biological therapies audit. Using the data from 61 patients who had stoma, we identified 5 stoma specific questions for the CUCQ-12 plus. The CUCQ-12 demonstrated good internal consistency (Cronbach’s α = 0.86); had good reproducibility (intra-class correlation coefficient = 0.74); was well correlated with the EQ5D (r = - 0.48), HBI (r = 0.45), and SCCAI (r = 0.43); and had good responsiveness statistics (> 0.5).
CUCQ-12 is a valid and reliable QoL measure that can be used for all patients with IBD in clinical practice including patients with stoma.