P481 Effect of anti-TNFα therapy with daily physical activity in patients with Crohn’s disease
F. A. Lucca, C. Malaguti, A. L. Cabalzar, L. A. Chebli, T. C. R. Ribeiro*, P. D. Gaburri, J. M. F. Chebli
Universidade Federal de Juiz de Fora, Gastroenterology, Juiz de Fora, Brazil
Crohn’s disease (CD) is a chronic inflammatory bowel disease, marked by exacerbations and remissions periods. Multiple factors as disease activity, corticosteroids therapy, underlying anaemia, malnutrition, and muscle fatigue predispose to physical inactivity and sedentary lifestyle in this population. Moreover, it is unclear whether achieving disease remission patients will become physically more active. We aim to assess the effect of treatment with anti-TNFα regarding physical activity in moderate-to-severe CD patients.
We prospectively evaluate 23 CD patients at baseline and at 6 months after infliximab treatment on a regimen of induction at 0, 2, and 6 weeks followed by maintenance therapy each 8 weeks. The patients were evaluated according to Harvey–Bradshaw Index (HBI) and Inflammatory Bowel Disease Quality of Life Score (IBDQ), and underwent the recording of the steps/day number and activity time/day obtained by monitor of activities (Dynaport accelerometer) during 5 consecutive days.
Patients with CD achieved reduction in HBI scores compatible with disease remission, as well increased IBDQ scores suggesting improvement of quality of life after treatment with infliximab. However, they did not show increase in daily activity time (241.4 ± 91.9 vs 242.5 ± 88.0 min/day; p > 0.005) and in the steps/day number (6 838 ± 3 178 vs 7 358 ± 2 984 steps/day; p > 0.005).
Although patients achieved disease remission and improvement in quality of life, they did not become more physically active. This finding can indicate that patients with CD are more sedentary regardless of appropriate disease control.