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P512 The prevalence and risk factors of gallstone disease in patients with ulcerative colitis

B. I. Jang*1, K. O. Kim1, C. H. Yang2, Y. H. Jung1

1Yeungnam University College of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Daegu, South Korea, 2Dongguk University College of Medicine, Division of gastroenterology and Hepatology, department of Internal Medicine, Kyungju, Korea, Republic of


Although high prevalence of gallstone disease in patients with Crohn’s disease has been recognised, the prevalence and risk in patients with ulcerative colitis (UC) has not been completely evaluated. The aims of the present study were to evaluate the prevalence, risk factors, and the relative risk of gallstone disease in UC patients compared with controls.


The medical records of 311 patients with UC between January 2004 and February 2015 were reviewed, retrospectively. For assessing the relative risk, 622 subjects with age, gender, and body mass index matched were included as control group from our health promotion centre. All the patients and controls included underwent at least 1 hepatobiliary ultrasonogram. The history of abdominal surgery, prevalence of gallstone disease, and clinical outcome were evaluated.


Gallstone was detected in 8% (25/311) in the UC group and 3.9% (24/622) in the control group, respectively. The prevalence of gallstone was significantly higher in the UC group (OR 2.178, p = 0.007). Mean age of the patients with gallstone was 57.1 ± 17.8 years; in UC group, the mean disease duration was 67.2 ± 38.8 months. Male to female ratio of the patients with gallstone in the UC group was 17:8. Mean duration from diagnosis of UC to detection of gallstone was 17.8 ± 30 months. Amongst 25 UC patients with gall stone, 6 patients underwent cholecystectomy or ERCP (endoscopic retrograde cholangiography) for symptomatic disease and complications. By univariate analysis, diabetes, hypertension, and admission history ≥ 3 times were significantly associated with gallstone in patients with UC. However, only hospitalisation ≥ 3 times reached statistical significance as a risk factor by multivariate analysis (OR 4.1, p = 0.001). Disease activity, total parenteral nutrition history, disease extent, and duration of disease were not significantly associated.


The present study show that patients with UC have significant higher risk of gallstone compare with the general population group. Having multiple admission history associated with UC is especially associated with increased the risk of gallstone disease.