P670 Mortality and its predictors in inflammatory bowel disease: a hospital-based cohort study from Korea 1977–2013
H.-S. Lee*1, J. W. Choe1, H. J. Lee1, K. Chang2, G.-U. Kim2, S. W. Hwang2, S. H. Park2, D.-H. Yang2, K.-J. Kim2, B. D. Ye2, J.-S. Byeon2, S.-J. Myung2, S.-K. Yang2
1Asan Medical Centre, University of Ulsan College of Medicine, Health Screening and Promotion Centre, Seoul, South Korea, 2Asan Medical Centre, University of Ulsan College of Medicine, Department of Gastroenterology, Seoul, South Korea
In a non-Caucasian population, data for mortality of inflammatory bowel disease (IBD) are limited. We aimed to evaluate mortality and its predictive factors in a well-defined hospital-based cohort of Korean IBD patients.
We retrieved data from the Asian IBD Registry to analyse mortality in 5 212 Korean patients with IBD (2 798 with ulcerative colitis [UC] and 2 414 with Crohn’s disease [CD]) who were diagnosed between 1977 and 2013. Next, we compared their mortality with that of the entire Korean population, which was derived from the Korean Statistical Information Service. Standardised mortality ratios (SMRs), observed/expected deaths, were calculated for demographic and phenotypic subgroups.
During a mean follow-up of 9 years (9.4 years for UC and 8.6 years for CD), 107 deaths (74 with UC and 33 with CD) were identified. The overall SMR was 0.68 (95% confidence interval [CI] 0.54–0.86) in UC and 1.32 (95% CI 0.91–1.85) in CD. In UC, male sex, age at diagnosis ≥ 30 years, and proctitis at diagnosis were associated with a reduced risk of mortality, compared with general population. In contrast, mortality increased in UC patients with primary sclerosing cholangitis. In CD, factors associated with higher mortality rates were female sex and use of corticosteroids.
Korean patients with CD showed a trend towards higher mortality compared with the general Korean population. In contrast, the overall mortality in Korean patients with UC was lower than that in the general Korean population. Considering that our result is demonstrated from referral hospital-based cohort, Korean UC patients may have a better prognosis with regard to mortality compared with Western UC patients.