P699 Health-related quality of life in inflammatory bowel disease in a Danish population-based inception cohort
L. Christiansen*, F. Bendtsen, J. Burisch, M. Kajbaek Vester-Andersen
Hvidovre University Hospital, Department of Gastroenterology, Hvidovre, Denmark
Ulcerative colitis (UC) and Crohn’s disease (CD) negatively affect patients’ health-related quality of life (HRQoL). Only few published population-based cohort studies have compared disease activity and social factors such as work status, employment status, and sick leave with HRQoL. The aim of the present study was to determine HRQoL in a population-based inception cohort of UC and CD patients after a 7-year follow- up (FU) period.
In total, 513 patients diagnosed with inflammatory bowel disease (IBD) between January 1, 2003, and December 31, 2004, in a well-defined area in Copenhagen were included in the cohort.1,2 Clinical and demographic data were registered at inclusion and all medical records from the FU period were reviewed. Patients were asked to complete the generic Short Form-12 (SF-12), the disease-specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ), and 2 questionnaires regarding social factors at 7-year follow-up. The association amongst relevant clinical, demographic, and social factors and HRQoL were examined through linear regression analyses.
In total, 368 patients were eligible for 7-year FU of which 185 patients (107 UC and 78 CD) completed the HRQoL questionnaires (response rate: 50%) and were included in the present study. Except for female gender in UC patients, no differences were found between responders and non-responders to the self-administrated-questionnaires. Further, 18% of CD patients and 7% of UC patients reported being unemployed ≥ 12 months during the last 3 years of FU, and 17 % of CD patients and 11 % of UC patients reported sick leave ≥ 3 months during the last 3 years of FU. In addition, 38% had a severe disease course during FU. HRQoL scores are shown in Table 1. SF-12 scores were not significantly reduced compared with a healthy reference population. Mean SIBDQ scores were above 50, thus indicating good HRQoL. Reporting sick leave and unemployment during FU was significantly associated with lower HRQoL. No association between disease activity or phenotype and lower HRQoL was found.
Table 1 Mean scores (SD) for the SF-12 and SIBDQ
|- PCS-12||49.1 (10.2)||49.7 (10.0)|
|- MCS-12||49.6 (10.6)||52.1 (9.0)|
|SIBDQ||55.6 (11.9)||57.9 (10.3)|
|- Bowel||16.6 (11.9)||16.8 (10.3)|
|- Systemic||9.8 (3.2)||10.9 (2.7)|
|- Emotional||16.8 (4.1)||17.4 (3.2)|
|- Social||12.5 (2.4)||12.8 (2.6)|
In this population-based inception cohort, IBD patients generally experienced good HRQoL compared with a healthy background population after 7 years FU. Unemployment and sick leave are related to patients’ generic and disease-specific HRQoL in a negative way. Disease activity and phenotype were without influence on HRQoL.
 Vester-Andersen MK, Michelle V, Prosberg MV, Jess T, et al. Disease course and surgery rates in inflammatory bowel disease: a population-based, 7-year follow-up study in the era of immunomodulating therapy. Am J Gastroenterol 2014;109:705–14.
 Vester-Andersen, MK, Vind I, Prosberg MV, et al. Hospitalisation, surgical and medical recurrence rates in inflammatory bowel disease 2003–2011—A Danish population-based cohort study. J Crohns Colitis 2014;8(12)1675–83.
- Posted in: Poster presentations: Epidemiology (2016)