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* = Presenting author

P710 Evolution of the incidence of inflammatory bowel disease in the south of Spain in 2 periods

D. Chaaro*1, J. M. Benitez2, R. Perea Amarillo1, F. Argüelles Arias1, L. Castro Laria1, M. B. Maldonado Perez1, V. García Sanchez2, E. Iglesias Flores2, A. Benitez Roldan1, A. Caunedo Álvarez1

1University Hospital Virgen Macarena, Gastroenterology and Hepatology Department, Seville, Spain, 2University Hospital Reina Sofía, Gastroenterology and Hepatology Department, Cordoba, Spain

Background

An increase in the incidence of inflammatory bowel disease (IBD) in Spain has been reported. No current data are available, especially in the south. Aim: to analyse the evolution of the incidence of IBD in the south of Spain from 1995 to 2014.

Methods

We conducted a retrospective study to establish the evolution of the incidence of IBD was carried out in 2 hospitals in the south of Spain. The databases of the 2 hospitals were reviewed over 2 periods of time (from 1995 to 2000 and from 2001 to 2014) and compared. The variables age, sex, smoking, localization of disease at diagnosis, and family history of IBD and were tested and compared between the 2 periods of time. Inclusion criteria were age more than 14 year and a clinical diagnosis of IBD.

Results

The population of both hospitals was 1 011 555 habitants, and 2 519 patients were collected. In the first period, 430 patients were registered. The total incidence rate was 7.07 per 100 000 person-years. Ulcerative colitis (UC) incidence was 3.57 per 100 000 person-years, and Crohn’s disease (CD) incidence was 3.50 per 100 000 person-years. UC was diagnosed in 50.4% (n = 217). In the second period, 2 089 patients were registered. The incidence of IBD was 14.7 per 100 000 person-years. The incidence of UC was 7.6 per 100 000 person-years, and 7.1 cases per 100 000 person-years for CD patients. UC was diagnosed in 51.7% (n = 1 081). Epidemiological data are shown in Figure 1. Comparing both periods of time, the incidence has doubled with statistically significant differences (Figure 2). Regarding the epidemiological data, statistically significant differences between both periods was found in the following variables: age, family history of IBD, and localisation of UC at diagnosis (p < 0.05).

Figure 1. Epidemiological data.

Figure 2. Incidence cumulative rates.

Conclusion

The incidence of IBD in the south of Spain has dramatically increased since 1995, and the finding is similar to the data reported in other European countries. Some differences have been found between the 2 periods (age at diagnosis, family history, and localisation). Because it is a retrospective study, selection bias cannot be ruled out.