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P714 Risk factors for vitamin D, zinc, and selenium deficiency in the patients with inflammatory bowel disease

Y. M. Han1, H. Yoon*2, S. Lim3, M.-k. Sung4, C. M. Shin3, Y. S. Park3, N. Kim1, 3, D. H. Lee1, 3, J. S. Kim1

1Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, South Korea, 2Seoul National University Bundang Hospital, Departments of Internal Medicine, Seongnam, South Korea, 3Seoul National University Bundang Hospital, Departments of Internal medicine, Seongnam, South Korea, 4Sookmyung Women’s University, Department of Food and Nutrition, Seoul, South Korea

Background

Studies on micronutrients status in Asian patients with inflammatory bowel disease (IBD) have been scarce. The aim of this study was to evaluate serum concentrations of vitamin D, zinc, and selenium in Korean patients with IBD.

Methods

We measured the serum level of 25-hydroxy-vitamin D3 (25-OHD), zinc, and selenium in consecutive IBD patients and analysed clinical risk factors for lower levels of these micronutrients than reference values. In addition, we compared the 25-OHD level of IBD patients with those of age- and sex-matched healthy control.

Results

Between 2013 and 2015, 83 IBD patients (34 with Crohn’s disease and 49 with ulcerative colitis) were enrolled. Further, 74 patients (89.2%) had suboptimal level of serum 25-OHD (vitamin D insufficiency 25-OHD 10–19.9 ng/mL) 49.4%, vitamin D deficiency (25-OHD < 10 ng/mL) 39.8%]. The mean serum level of 25-OHD in IBD patients was significantly lower than those in the healthy control group (12.3 ± 6.2 ng/mL vs 20.0 ± 6.7 ng/mL, p < 0.001). Proportion of patients with lower levels of serum zinc and selenium than reference values (70 ug/dL and 95 ug/L) was 39.0% and 30.9%, respectively. In multivariate logistic regression analysis, female gender (relative risk [RR], 4.735; 95% confidence interval [CI], 1.414–15.857; p = 0.012] and patients with Crohn’s disease (RR, 4.012; 95% CI, 1.352–11.900; p = 0.012) were associated with vitamin D deficiency. Patients under 40 years old showed increased risk of zinc deficiency (RR, 3.683; 95% CI, 1.152–11.777; p = 0.045). Female gender (RR, 4.871; 95% CI, 1.352–17.544; p = 0.015) and low serum albumin level (< 3.3 g/dL) (RR, 10.346; 95% CI, 1.035–1034– 47; p = 0.047) were the risk factors for selenium deficiency.

Table 1 Univariate and multivariate analysis of risk factors for vitamin D deficiency in IBD patients

Table 2 Univariate and multivariate analysis of risk factors for zinc deficiency in IBD patients

Conclusion

A considerable proportion of Korean IBD patients showed vitamin D, zinc, and selenium deficiency, suggesting the necessity for monitoring and supplementation of these micronutrients in IBD patients.