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N809 IBD control questionnaire: validation and evaluation as part of a virtual biologic clinic in Galway University Hospital, Ireland

Keogh A., Burke M.

Galway University Hospital, Gastroenterology, Galway, Ireland

Background

Patient-reported outcome measures in clinical practice are increasingly advocated as a means of supporting patient-centred care. The IBD-Control Questionnaire measures overall disease control (in the previous 2 weeks) from the patient's perspective. As part of a new consultant led virtual biologic clinic (VBC) we aimed to validate the IBD Control Questionnaire in our VBC, specifically the IBD Control-8 and VAS subscales.

Methods

In a single-centre retrospective study 60 randomly selected questionnaires were reviewed of patients receiving biologics. The questionnaire consisted of the IBD-Control questionnaire and Mayo score or Harvey Bradshaw Index. CRP levels were also recorded. In IBD-Control8, ≥13 points and IBD-Control VAS ≥85 points identified patients with inactive IBD.

Results

Mean age was 41, diagnosis UC = 26, Crohn's = 34 receiving biologics. Disease activity was categorised as per Mayo, HBI and IBD Control. There was a strong correlation between the IBD Control-8 and VAS, p≤0.001. A negative correlation was identified between CRP and VAS, p<0.001. A one way between groups ANOVA of the Mayo and VAS scores revealed a statistically significant difference between two groups (remission, moderate/severe). Analysis for the Crohn's cohort revealed a statistically significant difference between all three groups, p<0.001. Standard multiple regression was used to assess the IBD 8 and CRP levels to predict overall control in the past two weeks. Both independent variables made a statistically significant contribution. However the IBD8 variable recorded a higher beta value (0.69) than CRP levels (0.3)

Conclusion

A strong correlation was shown between the IBD Control measure with both the Mayo and HBI. With a moderate correlation with VAS and CRP levels. While both CRP and VAS contributed to the regression model, VAS scores were revealed as the stronger predictor of IBD control. IBD Control has strong measurement properties and is easily administered. Its introduction in our VBC has been very positive from both patient and staff perspectives. The findings illuminate the importance of incorporating clinical and patient reported measures in terms of patient management.