OP037 Infants born to mothers with inflammatory bowel disease exhibit distinct microbiome features that persist up to 3 months of life
Torres J.*1, Hu J.2, Eisele C.2, Nair N.2, Panchal H.2, Bao X.2, Niu X.2, Côté-Daigneault J.1, Jharap B.1, Maser E.1, Kornbluth A.1, Legnani P.1, George J.1, Dubinsky M.3, Stone J.4, Chen C.-L.4, Clemente J.2,5, Colombel J.-F.1, Peter I.2
1Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States 2Icahn School of Medicine at Mount Sinai, Genetics and Genomic Sciences, New York, United States 3Icahn School of Medicine at Mount Sinai, Department of Pediatrics, New York, United States 4Icahn School of Medicine at Mount Sinai, Obstetrics, Gynecology and Reproductive Science, New York, United States 5Icahn School of Medicine at Mount Sinai, Immunology, New York, United States
Human studies have demonstrated changes in the diversity and abundance of the microbiome during pregnancy coinciding with changes in maternal immune status. Furthermore, accumulating evidence suggests that maternal health may influence the newborn's microbiome development. These balancing acts may be even more complicated in pregnant women with IBD, who exhibit a variety of immunological and gut microbiota alterations. Yet, no data exist on the effect of IBD on the microbiome during pregnancy, and its role on the infant gut microbiota composition.
125 pregnant women (43 with IBD) and 79 babies (26 born to mothers with IBD) were included; 193 maternal samples (148 stool, 45 placenta) and 245 infant stool samples were analyzed. Among all babies, 35.4% were born via C-section and 96% were full-term. Even though 74% of women with IBD were in remission throughout pregnancy, this group presented lower bacterial diversity (p=0.001, ANOVA), and different overall bacterial composition in stool (p=0.001; PERMANOVA, unweighted Unifrac), with enrichment in
IBD women maintain dysbiosis in their gut microbiota during pregnancy, and present with different placental microbiome. Babies born to mothers with IBD demonstrate different gut microbiome composition that persists for up to 3 months of life, and is independent of mode of delivery. These findings suggest that maternal IBD status affects the gut microbiome composition in offspring, which could contribute to future disease risk.