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P139 Articular manifestations in inflammatory bowel disease – results from Northeastern Romania

Cardoneanu A.*1, Rezus E.1, Gavrilescu O.2, Cijevschi-Prelipcean C.2, Dranga M.2, Badescu A.3, Drug V.2, Stanciu C.2, Trifan A.2, Mihai C.2

1University of Medicine and Pharmacy Gr. T. Popa Iasi, Rheumatology, Iasi, Romania 2University Of Medicine And Pharmacy Gr. T. Popa, Department of Gastroenterology, Iasi, Romania 3University Of Medicine And Pharmacy Gr. T. Popa, Microbiology, Iasi, Romania

Background

The presence of extraintestinal manifestations (EIM) in inflammatory bowel disease (IBD) is a common and well known finding. Among these, joint involvement is one of the most frequently associated.

Methods

Using the national database IBD Prospect, we conducted a prospective case-control study that included 325 patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC). Between these cases, 81 (24.92%) were classified in the group CD, 242 (74.46%) having UC and 2 cases (0.62%) were classified as having undifferentiated colitis Among them, 30 patients (9,23%) had EIM including 24 cases of articular manifestations. Regarding joint events, we found 5 cases of arthiris, 10 cases having axial manifestations like sacroiliitis or ankylosing spondylitis and 9 cases of multiple EIM including articular damage.

Results

In both study arms, articular manifestations occupy the first place into EIM (14/17 CD vs 10/13 UC, 82.35% vs 76.92%, p=0.927). Into the group of CD patients, joint manifestations first correlated with the ileo-colonic form of CD (8/14; 57,14%) followed by the colonic involvement (4/14; 28,57%). Into the UC arm, joint damage was associated with an extended colonic involvement (4/10; 40%) followed by proctitis and left side colitis. Both groups of patients with articular manifestations were associated with a moderate form of IBD activity - 10/14 CD vs 5/10 UC (71.43% vs 50%, p=0.199).

Conclusion

In Northeastern Romania predominate UC cases. Most patients included in this study and having EIM belong to CD phenotype. Articular manifestations occurred at a higher frequency in patients with CD as compared to those diagnosed with UC. The most common articular manifestation is the axial involvement, followed by peripheral arthritis.